Results 121 to 130 of about 440,600 (338)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

SPYGLASS. VI. Feedback-driven Star Formation in the Circinus Complex

The Astrophysical Journal
Young associations provide a record that traces the star formation process, and the youngest populations connect progenitor gas dynamics to the resulting stellar populations.
Ronan Kerr, Juan P. Farias, Lisa Prato, Travis A. Rector, Joshua S. Speagle, Adam L. Kraus   +5 more
doaj   +1 more source

Asymmetric Star Formation Efficiency Due to Ram Pressure Stripping

Galaxies, 2016
Previous works have shown that a dense cluster environment affects satellite galaxy properties and accelerates or truncates their evolutionary processes.
Paulina Troncoso Iribarren, Nelson Padilla, Sergio Contreras, Silvio Rodriguez, Diego García-Lambas, Claudia del P. Lagos   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Old star clusters: Bench tests of low mass stellar models

EPJ Web of Conferences, 2013
Old star clusters in the Milky Way and external galaxies have been (and still are) traditionally used to constrain the age of the universe and the timescales of galaxy formation.
Salaris M.
doaj   +1 more source

On the X-ray Emission from Massive Star Clusters and their Evolving Superbubbles

, 2005
The X-ray emission properties from the hot thermalized plasma that results from the collisions of individual stellar winds and supernovae ejecta within rich and compact star clusters are discussed.
Gabriel Alejandro Anorve‐Zeferino, Guillermo Tenorio‐Tagle, Ho L. C., Ozernoy L. M., Sergiy Silich, Van Bever J.   +5 more
core   +2 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Testing Cluster Membership of Planetary Nebulae with High-precision Proper Motions. I. HST Observations of JaFu 1 Near the Globular Cluster Palomar 6

The Astronomical Journal
If a planetary nebula (PN) is shown to be a member of a star cluster, we obtain important new constraints on the mass and chemical composition of the PN’s progenitor star, which cannot be determined for PNe in the field.
Howard E. Bond, Andrea Bellini, Kailash C. Sahu   +2 more
doaj   +1 more source

THE STAR FORMATION HISTORY OF THE MILKY WAY'S NUCLEAR STAR CLUSTER [PDF]

, 2011
O. Pfuhl, T. K. Fritz, Miri Zilka, H. Maness, F. Eisenhauer, R. Genzel, S. Gillessen, Thomas Ott, K. Dodds-Eden, A. Sternberg   +9 more
openalex   +1 more source