Results 131 to 140 of about 440,600 (338)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Kinematical and dynamical properties of recently discovered bulge and disc star clusters with WINERED

Astronomy & Astrophysics
Context. Galactic globular clusters are a very important tool in explaining the characteristics of the Milky Way. Therefore it is essential to determine the kinematical and dynamical properties of the new star cluster candidates, especially at the low ...
Petralia Ilaria, Minniti Dante, Fernández-Trincado José G., Matsunaga Noriyuki, Taniguchi Daisuke, Saroon Sasi, Garro Elisa R., Sameshima Hiroaki, Otsubo Shogo, Sarugaku Yuki, Takeuchi Tomomi   +10 more
doaj   +1 more source

CAIRNS: The Cluster And Infall Region Nearby Survey III. Environmental Dependence of H-alpha Properties of Galaxies

, 2005
We investigate the environmental dependence of star formation in cluster virial regions and infall regions as part of CAIRNS (Cluster And Infall Region Nearby Survey), a large spectroscopic survey of the infall regions surrounding nine nearby rich ...
Antonaldo Diaferio, Ebeling H., Fukazawa Y., Godwin J., Goto T., Kenneth Rines, Koopmann R., Margaret J. Geller, Michael J. Kurtz   +8 more
core   +1 more source

Recurrent gas accretion by massive star clusters, multiple stellar populations and mass thresholds for spheroidal stellar systems [PDF]

, 2009
Jan Pflamm-Altenburg, Pavel Kroupa
openalex   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

A stochastic Monte Carlo approach to modelling real star cluster evolution -- III. Direct integration of three- and four-body interactions [PDF]

, 2003
Mirek Giersz, Rainer Spurzem
openalex   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A stochastic Monte Carlo approach to model real star cluster evolution--II. Self-consistent models and primordial binaries [PDF]

, 2000
Mirek Giersz, Rainer Spurzem
openalex   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source