Results 101 to 110 of about 91,664 (267)

NEW CLUES TO THE CAUSE OF EXTENDED MAIN-SEQUENCE TURNOFFS IN INTERMEDIATE-AGE STAR CLUSTERS IN THE MAGELLANIC CLOUDS

, 2014
Matteo Correnti, Paul Goudfrooij, Jason S. Kalirai, Leo Girardi, Thomas H. Puzia, Leandro Kerber   +5 more
openalex   +2 more sources

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Mapping the Star Formation and H i Gas Properties of Galaxies along Large-scale Structures around the Virgo Cluster

The Astrophysical Journal
We investigate the star formation and neutral atomic hydrogen (H i ) gas properties of galaxies along three large-scale filaments and two galaxy groups in the wide field around the Virgo cluster.
Hyein Yoon, O. Ivy Wong, Aeree Chung, Shan Huang   +3 more
doaj   +1 more source

From the top down and back up again: star cluster structure from hierarchical star formation. [PDF]

Mon Not R Astron Soc, 2018
Grudić MY, Guszejnov D, Hopkins PF, Lamberts A, Boylan-Kolchin M, Murray N, Schmitz D.   +6 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Star and Stellar Cluster Formation: ALMA-SKA Synergies [PDF]

, 2015
G. A. Fuller, Jan Forbrich, J. M. Rathborne, Steven N. Longmore, S. Molinari   +4 more
openalex   +1 more source

Bar-Driven Star and Star Cluster Formations and Gas Fueling to Galactic Center [PDF]

, 2021
Hidenori Matsui, Toshiyasu Masakawa, Asao Habe, Takayuki R. Saitoh   +3 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Seeding Cores: A Pathway for Nuclear Star Clusters from Bound Star Clusters in the First Billion Years

The Open Journal of Astrophysics
We model the formation of star clusters in a dwarf galaxy progenitor during the first 700 Myr of cosmic history using a cosmological radiation-hydrodynamic simulation with a sub-grid star formation efficiency (SFE) model calibrated from AU-scale ...
Fred Angelo Batan Garcia, Massimo Ricotti, Kazuyuki Sugimura   +2 more
doaj   +1 more source