Results 131 to 140 of about 429,563 (275)

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

open access: yesMolecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck   +12 more
wiley   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

open access: yesMolecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto   +8 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

On the Orbital Effects of Stellar Collisions in Galactic Nuclei: Tidal Disruption Events and Ejected Stars

open access: yesThe Astrophysical Journal Letters
Dense stellar clusters surround the supermassive black holes (SMBH) in galactic nuclei. Interactions within the cluster can alter the stellar orbits, occasionally driving a star into the SMBH’s tidal radius, where it becomes ruptured, or expelling a star
Sanaea C. Rose, Brenna Mockler
doaj   +1 more source

STAR-FORMING GALAXIES IN THE HERCULES CLUSTER: Hα IMAGING OF A2151 [PDF]

open access: bronze, 2009
Bernabé Cedrés   +11 more
openalex   +1 more source

Open Star Clusters and Their Asymmetrical Tidal Tails

open access: yesThe Astrophysical Journal
Stars that evaporate from their star cluster by the energy equipartition process end up in either a leading or a trailing tidal tail. In Newtonian gravitation and for open star clusters in the solar vicinity, the tidal threshold, or práh, for escape is ...
Pavel Kroupa   +6 more
doaj   +1 more source

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