Results 61 to 70 of about 91,664 (267)

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Truncated Star Formation and Ram Pressure Stripping in the Coma Cluster

The Astrophysical Journal
We use 45 galaxies from the Mapping Nearby Galaxies at Apache Point Observatory survey to study the physical drivers of star formation quenching in the Coma Cluster.
Ariel O. Broderick, Ian D. Roberts, Michael J. Hudson   +2 more
doaj   +1 more source

Asymmetric Star Formation Efficiency Due to Ram Pressure Stripping

Galaxies, 2016
Previous works have shown that a dense cluster environment affects satellite galaxy properties and accelerates or truncates their evolutionary processes.
Paulina Troncoso Iribarren, Nelson Padilla, Sergio Contreras, Silvio Rodriguez, Diego García-Lambas, Claudia del P. Lagos   +5 more
doaj   +1 more source

A universal route for the formation of massive star clusters in giant molecular clouds [PDF]

, 2018
Corey S. Howard, Ralph E. Pudritz, William E. Harris   +2 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

SPYGLASS. VI. Feedback-driven Star Formation in the Circinus Complex

The Astrophysical Journal
Young associations provide a record that traces the star formation process, and the youngest populations connect progenitor gas dynamics to the resulting stellar populations.
Ronan Kerr, Juan P. Farias, Lisa Prato, Travis A. Rector, Joshua S. Speagle, Adam L. Kraus   +5 more
doaj   +1 more source

Old star clusters: Bench tests of low mass stellar models

EPJ Web of Conferences, 2013
Old star clusters in the Milky Way and external galaxies have been (and still are) traditionally used to constrain the age of the universe and the timescales of galaxy formation.
Salaris M.
doaj   +1 more source

Star cluster evolution, dynamical age estimation and the kinematical signature of star formation [PDF]

, 1995
Pavel Kroupa
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source