Results 111 to 120 of about 71,711 (296)

Plasma lipidomic and metabolomic profiles in high‐grade glioma patients before and after 72‐h presurgery water‐only fasting

Molecular Oncology, EarlyView.
Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé, Lisa Hahnefeld, Katharina J. Wenger, Donat Kögel, Joachim Steinbach, Gerd Geisslinger, Michael W. Ronellenfitsch, Irmgard Tegeder   +7 more
wiley   +1 more source

A JWST Project on 47 Tucanae: NIRSpec Spectroscopy of Multiple Populations among M Dwarfs

The Astrophysical Journal Letters
We present the first spectroscopic estimates of the chemical abundance of M dwarf stars in a globular cluster (GC), namely 47 Tucanae. By exploiting NIRSpec on board the James Webb Space Telescope, we gathered low-resolution spectra for 28 stars with ...
A. F. Marino, A. P. Milone, A. Renzini, E. Dondoglio, E. Bortolan, M. G. Carlos, G. Cordoni, A. Dotter, S. Jang, E. P. Lagioia, M. V. Legnardi, F. Muratore, A. Mohandasan, M. Tailo, T. Ziliotto   +14 more
doaj   +1 more source

The Structure of the Globular Star Clusters [PDF]

, 1945
E. Finlay-Freundlich
openalex   +1 more source

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

A Thorough Exploration of the Metal-rich Massive Open Cluster NGC 6253: Focusing on Membership, Binaries, Stragglers, and Mass Function

The Astrophysical Journal
This study provides an in-depth analysis of the ancient open galactic cluster NGC 6253, characterized by the presence of both blue and yellow straggler stars.
Huanbin Chi, Feng Wang
doaj   +1 more source

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Neutral Hydrogen in Galactic Star Clusters: I. A Search for Neutral and Ionized Hydrogen in Five Galactic Clusters [PDF]

, 1963
R. D. Davies, H. M. Tovmassian
openalex   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

Binary Disruption and Ejected Stars from Hierarchical Star Cluster Assembly

The Astrophysical Journal
We simulate mergers between star clusters embedded within their natal giant molecular cloud. We extract initial conditions from cloud-scale simulations of cluster formation and introduce different prescriptions for primordial binaries.
Claude Cournoyer-Cloutier, Jeremy Karam, Alison Sills, Simon Portegies Zwart, Maite J. C. Wilhelm   +4 more
doaj   +1 more source