Results 91 to 100 of about 4,646,373 (300)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

PHANGS-JWST first results: spurring on star formation: JWST reveals localized star formation in a spiral arm spur of NGC 628

, 2022
International audienceWe combine JWST observations with Atacama Large Millimeter/submillimeter Array CO and Very Large Telescope MUSE Hα data to examine off-spiral arm star formation in the face-on, grand-design spiral galaxy NGC 628.
Hassani, Hamid, Leroy, Adam, K, Pessa, Ismael, Meidt, Sharon, E, Querejeta, Miguel, Cao, Yixian, Larson, Kirsten, L, Sandstrom, Karin, M, Watkins, Elizabeth, J, Smith, Rowan, Glover, Simon, C O, Bigiel, Frank, Jeffreson, Sarah, Sormani, Mattia, C, Kruijssen, J, M Diederik, Pinna, Francesca, Williams, Thomas, G, Barnes, Ashley, T, Emsellem, Eric, Sun, Jiayi, Rosolowsky, Erik, Klessen, Ralf, S, Stuber, Sophia, Schinnerer, Eva, Thilker, David, A, Chevance, Mélanie, Boquien, Médéric, Liu, Daizhong, Pety, Jérôme, Egorov, Oleg, V, Grasha, Kathryn, Jiménez-Donaire, María, J, Henshaw, Jonathan, D, Whitmore, Bradley, C, Kreckel, Kathryn, Blanc, Guillermo, A, Kim, Jaeyeon   +36 more
core   +1 more source

First Results from ALPPS: A Sub-Alfvénic Streamer in SVS 13A

The Astrophysical Journal Letters
We present the first results from the Atacama Large Millimeter/submillimeter Array Perseus Polarization Survey, focusing on the magnetic field in the SVS 13A circumbinary disk.
P. C. Cortés, J. E. Pineda, T.-H. Hsieh, J. J. Tobin, P. Saha, J. M. Girart, V. J. M. Le Gouellec, I. W. Stephens, L. W. Looney, E. Koumpia, M. T. Valdivia-Mena, L. Cacciapuoti, C. Gieser, S. S. R. Offner, P. Caselli, P. Sanhueza, D. Segura-Cox, M. Fernández-López, K. Morii, B. Huang, F. O. Alves, Q. Zhang, W. Kwon, C. L. H. Hull, Z.-Y. Li   +24 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Magnetic Fields in Massive Star-forming Regions (MagMaR). IV. Tracing the Magnetic Fields in the O-type Protostellar System IRAS 16547–4247

The Astrophysical Journal
The formation of the massive stars, and in particular, the role that the magnetic fields play in their early evolutionary phase is still far from being completely understood.
Luis A. Zapata, Manuel Fernández-López, Patricio Sanhueza, Josep M. Girart, Luis F. Rodríguez, Paulo Cortés, Patrick Koch, Maria T. Beltrán, Kate Pattle, Henrik Beuther, Piyali Saha, Wenyu Jiao, Fengwei Xu, Xing Walker Lu, Fernando Olguin, Shanghuo Li, Ian W. Stephens, Ji-hyun Kang, Yu Cheng, Spandan Choudhury, Kaho Morii, Eun Jung Chung, Jia-Wei Wang, Jihye Hwang, A-Ran Lyo, Q. Zhang, Huei-Ru Vivien Chen   +26 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Star clusters as age tracers of the age-metallicity relation of the small magellanic cloud [PDF]

, 2009
In my Thesis, I determined ages of Small Magellanic Cloud (SMC) star clusters that have formed during the galaxys entire lifetime.
Glatt, Katharina
core   +1 more source