Results 81 to 90 of about 4,646,373 (300)

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

The Gravoturbulent Interplay between Star Cluster Feedback and Sequential Star Formation in NGC 1569-A [PDF]

, 2023
Super star clusters dominate the dynamics and evolution in the central region of the galaxy NGC 1569. Recent studies have determined different ages and complex morphology within the clusters, allowing to create complicated structures of gas related with ...
Jesús Omar Hernández Prado
core  

Determining the Methanol Deuteration in the Disk Around V883 Orionis with Laboratory Measured Spectroscopy

The Astronomical Journal
Deuterium fractionation, as studied through mono-deuterated methanol, is frequently used as a diagnostic tool to trace the physical conditions and chemical evolution of interstellar sources. This study investigates methanol deuteration in the disk around
Shaoshan Zeng, Jae-Hong Jeong, Takahiro Oyama, Jeong-Eun Lee, Yao-Lun Yang, Nami Sakai   +5 more
doaj   +1 more source

Formation of cold giant planets around late M dwarfs via core accretion and the fate of inner rocky worlds

Astronomy & Astrophysics
Context. Modeling how cold giant planets form around M dwarfs remains a challenge, both because their protoplanetary disks can lack sufficient mass and because such planets are expected to migrate inward while interacting with the disk.
Sanchez M., van der Marel N., Lambrechts M., Paardekooper S., Miguel Y.   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

From filamentary networks to dense cores in molecular clouds: toward a new paradigm for star formation

, 2014
24 pages, 15 figures. Accepted for publication as a review chapter in Protostars and Planets VI, University of Arizona Press (2014), eds. H. Beuther, R. Klessen, C. Dullemond, Th.
Pineda, Jaime, S.-I. Inutsuka, Di Francesco, James, P. André, Pudritz, Ralph E., J. Di Francesco, Ward-Thompson, D., D. Ward-Thompson, J. Pineda, André, Philippe, Inutsuka, Shu-Ichiro, R. E. Pudritz   +11 more
core   +1 more source

Origin of the Shell Structure in the Primary Outflow from IRAS 15398−3359

The Astrophysical Journal
IRAS 15398−3359, a Class 0 protostar in the Lupus I star-forming region, is associated with three generations of outflows. The primary outflow, i.e., the most recent one, shows an internal structure named the “shell structure” in the near-infrared ...
Tomoyuki Hanawa, Yuki Okoda, Yao-Lun Yang, Nami Sakai   +3 more
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source