Results 111 to 120 of about 993,735 (252)

The ALMA-ATOMS Survey: Methanol Emission in a Large Sample of Hot Molecular Cores

The Astrophysical Journal
Methanol (CH _3 OH) is a key complex organic molecule (COM) in the interstellar medium, widely used as a tracer of dense gas and hot molecular cores (HMCs).
Jiahang Zou, Tie Liu, Sheng-Li Qin, Yaping Peng, Fengwei Xu, Xunchuan Liu, Li Chen, Xindi Tang, Sami Dib, Zi-Yang Li, Hong-Li Liu, Mika Juvela, Patricio Sanhueza, Pablo Garcia, Chang Won Lee, Guido Garay, Swagat R. Das, Yan-Kun Zhang, Kee-Tae Kim, Jeong-Eun Lee, Meizhu Liu, Leonardo Bronfman, Zhiping Kou, Dongting Yang, Gang Wu, Jihye Hwang, Dezhao Meng, Mengyao Tang, James O. Chibueze   +28 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Cluster Formation in a Filamentary Cloud: The Case of the Stellar Cluster NGC 2316

The Astronomical Journal
We present a multiwavelength analysis of the star cluster NGC 2316 and its surroundings. We estimated the physical parameters of the NGC 2316 cluster, including its shape (elongated), size ( R _cluster = 0.4 pc), distance (1.3 ± 0.3 kpc), and minimum ...
Saurabh Sharma, Aayushi Verma, Kshitiz Mallick, Lokesh K. Dewangan, Harmeen Kaur, Ram Kesh Yadav, Neelam Panwar, Devendra K. Ojha, Tarak Chand, Mamta Agarwal   +9 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Tracing the History of Obscured Star Formation with the SIMBA Cosmological Galaxy Evolution Simulation

The Astrophysical Journal
We explore the cosmic evolution of the fraction of dust-obscured star formation predicted by the simba cosmological hydrodynamic simulations featuring an on-the-fly model for dust formation, evolution, and destruction.
Dhruv T. Zimmerman, Desika Narayanan, Katherine E. Whitaker, Romeel Davé   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Star Formation by Supernova Implosion

The Astrophysical Journal Letters
Recent hydrodynamical simulations of the late stages of supernova remnant (SNR) evolution have revealed that as they merge with the ambient medium, SNRs implode, leading to the formation of dense clouds in their center.
Leonard E. C. Romano, Andreas Burkert, Manuel Behrendt   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

High-redshift star formation in the Atacama large millimetre/submillimetre array era. [PDF]

R Soc Open Sci, 2020
Hodge JA, da Cunha E.
europepmc   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source