Results 131 to 140 of about 4,646,373 (300)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Temperature Variations in Star Forming Interstellar Cloud Cores

, 2020
In my dissertation, I have analysed the ammonia observations and the derived physical parameters of 36 Planck Galactic Cold Clumps, to search for systematic correlations between the calculated densities (NH3 column density, H2 volume density) and ...
Kushwahaa, Tanya
core  

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Sierra Club, Lone Star Chapter Newsletter

, 2019
Newsletter from the Lone Star Chapter of Sierra Club regarding Big Thicket Committee with an article titled "Big Thicket Expansion Sought" from the Lone Star SierranThe Big Thicket Collection contains materials relating to the conservation of the Big ...
Sierra Club, Lone Star Chapter
core   +1 more source

In Situ Formation of Star Clusters at z > 7 via Galactic Disk Fragmentation: Shedding Light on Ultracompact Clusters and Overmassive Black Holes Seen by JWST

The Astrophysical Journal Letters
We investigate the nature of star formation in gas-rich galaxies at z > 7 forming in a markedly overdense region, in the vicinity of a massive virialized halo already exceeding 10 ^12 M _⊙ , through the use of the very-high-resolution cosmological ...
Lucio Mayer, Floor van Donkelaar, Matteo Messa, Pedro R. Capelo, Angela Adamo   +4 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

S2D2: Small-scale, significant-substructure DBSCAN detection

Astronomy & Astrophysics
Context. The spatial analysis of young stellar objects (YSOs) has proven very valuable to describe and analyse star-forming regions and to understand the star formation process. Aims.
González Marta, Joncour Isabelle, Moraux Estelle, Motte Frédérique, Nespoli Elisa, Louvet Fabien, Valeille-Manet Maxime, Martínez-Badenes Vicent   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Star formation through cosmic space and time as traced by Milky Way progenitors

, 2017
In this work the close relation between cosmic star formation and the properties of galaxies is investigated in terms of feedback processes acting through cosmic space and time.
LUCA GRAZIANI, Matteo de Bennassuti, Raffaella Schneider   +2 more
core  

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source