Results 131 to 140 of about 194,114 (263)

GALAXY STRUCTURE, STELLAR POPULATIONS, AND STAR FORMATION QUENCHING AT 0.6 ≲ <i>z</i> ≲ 1.2. [PDF]

Astrophys J, 2018
Kim K, Malhotra S, Rhoads JE, Joshi B, Fererras I, Pasquali A.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Triggered Star Formation inside the Shell of a Wolf-Rayet Bubble as the Origin of the Solar System. [PDF]

Astrophys J, 2017
Dwarkadas VV, Dauphas N, Meyer B, Boyajian P, Bojazi M.   +4 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Evidence for Dark Energy Driven by Star Formation: Information Dark Energy? [PDF]

Entropy (Basel)
Gough MP.
europepmc   +1 more source

Triggered Star Formation inside the Shell of a Wolf-Rayet Bubble as the Origin of the Solar System. [PDF]

Proc Int Astron Union, 2018
Dwarkadas VV, Dauphas N, Meyer B, Boyajian P, Bojazi M.   +4 more
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

In-situ Star Formation in the Outskirts of the Large Magellanic Cloud: <i>Gaia</i> DR2 Confirmation. [PDF]

Astrophys J, 2018
Casetti-Dinescu DI, Girard TM, Bidin CM, Zhang L, Mendez RA, Vieira K, Korchagin VI, van Altena WF.   +7 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Star formation shut down by multiphase gas outflow in a galaxy at a redshift of 2.45. [PDF]

Nature
Belli S, Park M, Davies RL, Mendel JT, Johnson BD, Conroy C, Benton C, Bugiani L, Emami R, Leja J, Li Y, Maheson G, Mathews EP, Naidu RP, Nelson EJ, Tacchella S, Terrazas BA, Weinberger R.   +17 more
europepmc   +1 more source