Results 131 to 140 of about 5,548,804 (305)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Star formation through cosmic space and time as traced by Milky Way progenitors
, 2017 In this work the close relation between cosmic star formation and the properties of galaxies is investigated in terms of feedback processes acting through cosmic space and time.
LUCA GRAZIANI +2 more
core
A Natural Laboratory for Astrochemistry: The Variable Protostar B335
The Astrophysical Journal LettersEmission lines from complex organic molecules in B335 were observed in four epochs, spanning a luminosity burst of about 10 yr duration. The emission lines increased dramatically in intensity as the luminosity increased, but they have decreased only ...
Jeong-Eun Lee +5 more
doaj +1 more source
Star Formation Efficiency and Class I Protostellar Timescales in ATLASGAL Dense Clumps
UniverseStar formation in galactic dense clumps is commonly interpreted using nearly uniform protostellar evolutionary timescales, yet the extent to which such assumptions obscure variations in star formation efficiency remains uncertain. Using 60 ATLASGAL dense
Moses Onyemaechi Asogwa +3 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
STAR General Assembly February 2019
, 2019 Report of the STAR research unit General Assembly during the Second STAR ...
Grodent, Denis
core +1 more source
The Properties of an Edge-On Low Surface Brightness Galaxies Sample
UniverseWe analyzed the properties of a sample of edge-on low-surface brightness galaxies, which are referred to as Cao23 ELSBGs. Cao23 ELSBGs exhibit a wide range of luminosities (−22 < Mr < −13) with a mean scale length of 3.19 ± 1.48 kpc.
Tian-Wen Cao +7 more
doaj +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
The Astrophysical JournalIn this study, we consider the effects of ambipolar diffusion during the gravitational collapse of a radiative cooling filamentary molecular cloud. Two separate configurations of magnetic field, i.e., axial and toroidal, are considered in the presence of
Mahmoud Gholipour
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source