Results 141 to 150 of about 1,022,915 (352)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

THE STAR FORMATION HISTORY OF THE MILKY WAY'S NUCLEAR STAR CLUSTER [PDF]

open access: green, 2011
O. Pfuhl   +9 more
openalex   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

PHANGS-HST Catalogs for ∼100,000 Star Clusters and Compact Associations in 38 Galaxies. I. Observed Properties

open access: yesThe Astrophysical Journal Supplement Series
We present the largest catalog to date of star clusters and compact associations in nearby galaxies. We have performed a V -band-selected census of clusters across the 38 spiral galaxies of the PHANGS–Hubble Space Telescope (HST) Treasury Survey, and ...
Daniel Maschmann   +27 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

The ALMA-QUARKS Survey: Hot Molecular Cores Are a Long-standing Phenomenon in the Evolution of Massive Protostars

open access: yesThe Astrophysical Journal
We present an analysis of the QUARKS survey sample, focusing on protoclusters where hot molecular cores (HMCs; traced by CH _3 CN (12–11)) and HC/UC H ii regions (traced by H30 α /H40 α ) coexist.
Dezhao Meng   +37 more
doaj   +1 more source

An instability of feedback-regulated star formation in galactic nuclei [PDF]

open access: green, 2017
Paul Torrey   +6 more
openalex   +1 more source

Home - About - Disclaimer - Privacy