Results 141 to 150 of about 5,548,804 (305)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Most stars are born in the crowded environments of gradually forming star clusters. Dynamical interactions between close-passing stars and the evolving ultraviolet radiation fields from proximate massive stars are expected to sculpt the protoplanetary ...
Tan, Jonathan, +2 more
core +1 more source
Complex Organic Molecules in Protostars with ALMA Spectral Surveys (COMPASS)
Astronomy & AstrophysicsContext. Methyl cyanide (CH3CN) is one of the most abundant nitrogen-bearing complex organic molecules observed in the gas phase around both low- and high-mass protostars.
Nazari P. +18 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
High mass star formation in the galaxy [PDF]
, 1987 The Galactic distributions of HI, H2, and HII regions are reviewed in order to elucidate the high mass star formation occurring in galactic spiral arms and in active galactic nuclei.
Good, J. C., Scoville, N. Z.
core
The Astrophysical Journal LettersWe investigate the nature of star formation in gas-rich galaxies at z > 7 forming in a markedly overdense region, in the vicinity of a massive virialized halo already exceeding 10 ^12 M _⊙ , through the use of the very-high-resolution cosmological ...
Lucio Mayer +4 more
doaj +1 more source
FEBS Letters, EarlyView.Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell +2 more
wiley +1 more source