Results 141 to 150 of about 4,646,373 (300)

Revealing Multiple Nested Molecular Outflows with Rotating Signatures in HH270mms1-A with ALMA

open access: yesThe Astrophysical Journal
We present molecular line observations of the protostellar outflow associated with HH270mms1 in the Orion B molecular cloud with ALMA. The ^12 CO ( J = 3−2) emissions show that the outflow velocity structure consists of four distinct components of low ...
Mitsuki Omura   +2 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Unveiling a multi-scale view of massive star and cluster formation [Elektronisk resurs]

open access: yes
Massive stars regulate the physical and chemical evolution of galaxies. Most stars within these galaxies, including massive ones, appear to be born in star clusters.
Law, Chi Yan,
core  

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Outshining by recent star formation prevents the accurate measurement of high-z galaxy stellar masses

open access: yes
We demonstrate that the inference of galaxy stellar masses via spectral energy distribution (SED) fitting techniques for galaxies formed in the first billion years after the Big Bang carries fundamental uncertainties owing to the loss of star formation ...
Desika, Narayanan   +2 more
core  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

High mass star formation in the galaxy [PDF]

open access: yes, 1987
The Galactic distributions of HI, H2, and HII regions are reviewed in order to elucidate the high mass star formation occurring in galactic spiral arms and in active galactic nuclei.
Good, J. C., Scoville, N. Z.
core  

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