Results 121 to 130 of about 993,735 (252)

A Census of Star Formation in the Outer Galaxy. II. The GLIMPSE360 Field. [PDF]

Astron J, 2020
Winston E, Hora JL, Tolls V.
europepmc   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Parametrising Star Formation Histories

, 2014
We examine the star formation histories (SFHs) of galaxies in smoothed particle hydrodynamics (SPH) simulations, compare them to parametric models that are commonly used in fitting observed galaxy spectral energy distributions, and examine the efficacy ...
Conroy, Charlie, Dave, Romeel, Fardal, Mark, Katz, Neal, Oppenheimer, Benjamin D., Simha, Vimal, Weinberg, David H.   +6 more
core  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Structure and Dynamics of the Young Massive Star Cluster Westerlund 1

The Astrophysical Journal
We present a structural and dynamical analysis of the young massive star cluster Westerlund 1 (Wd1). Using multiepoch Hubble Space Telescope observations, we measure the proper motions of 10,346 stars and present an unprecedented determination of cluster
Lingfeng Wei, Peter C. Boyle, Jessica R. Lu, Matthew W. Hosek Jr., Quinn M. Konopacky, Richard G. Spencer, Dongwon Kim, Nicholas Z. Rui, Max Service, D. B. Huang, Jay Anderson   +10 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Violent Starbursts and Quiescence Induced by Far-ultraviolet Radiation Feedback in Metal-poor Galaxies at High Redshift

The Astrophysical Journal
JWST observations of galaxies at z ≳ 8 suggest that they are more luminous and clumpier than predicted by most models, prompting several proposals on the physics of star formation and feedback in the first galaxies. In this paper, we focus on the role of
Kazuyuki Sugimura, Massimo Ricotti, Jongwon Park, Fred Angelo Batan Garcia, Hidenobu Yajima   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Early-type Galaxies on the Star Formation Main Sequence: Internal Star Formation Geometries Revealed with MaNGA and Their Environmental Origin

The Astrophysical Journal
Star-forming galaxies on the main sequence (MS) are often regarded as a uniform population characterized by similar global star formation properties. However, there exists a diversity in galaxy morphologies at a fixed stellar mass and star formation rate.
Shuhei Koyama, Yusei Koyama, Takuji Yamashita, Masahiro Konishi, Kosuke Kushibiki, Kentaro Motohara   +5 more
doaj   +1 more source