Results 121 to 130 of about 5,183,495 (311)

The interaction-driven starburst contribution to the cosmic star formation rate density [PDF]

, 2013
A. Lamastra, N. Menci, F. Fiore, P. Santini   +3 more
openalex   +1 more source

The zinc finger domains of PARP‐1 are selectively and potently inhibited by the Au(I)‐based drugs sodium aurothiomalate and aurothioglucose

FEBS Letters, EarlyView.
PARP‐1 is a key enzyme in the DNA damage response, and its inhibition induces cancer cell death via synthetic lethality. Au(I)‐based drugs, such as aurothioglucose and sodium aurothiomalate, block PARP‐1's DNA‐dependent activity by targeting its zinc finger domains.
Uliana Bashtanova, Melinda Jane Duer
wiley   +1 more source

Molecular bases of circadian magnesium rhythms across eukaryotes

FEBS Letters, EarlyView.
Circadian rhythms in intracellular [Mg2+] exist across eukaryotic kingdoms. Central roles for Mg2+ in metabolism suggest that Mg2+ rhythms could regulate daily cellular energy and metabolism. In this Perspective paper, we propose that ancestral prokaryotic transport proteins could be responsible for mediating Mg2+ rhythms and posit a feedback model ...
Helen K. Feord, Gerben van Ooijen
wiley   +1 more source

Multiwavelength study of the star-formation in the bar of NGC 2903 [PDF]

, 2010
G. Popping, I. Perez, A. Zurita, G. Popping, I. Perez, A. Zurita   +5 more
openalex   +1 more source

Star formation in ‘the Brick’: ALMA reveals an active protocluster in the Galactic centre cloud G0.253+0.016 [PDF]

, 2021
Daniel L. Walker, S. N. Longmore, John Bally, Adam Ginsburg, J. M. Diederik Kruijssen, Qizhou Zhang, Jonathan D. Henshaw, Xing Lu, J. Alves, Ashley T. Barnes, Cara Battersby, H. Beuther, Y. Contreras, Laura Gómez, Luis C. Ho, James M. Jackson, Jens Kauffmann, Elisabeth A. C. Mills, T. Pillai   +18 more
openalex   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Structure and Dynamics of the Young Massive Star Cluster Westerlund 1

The Astrophysical Journal
We present a structural and dynamical analysis of the young massive star cluster Westerlund 1 (Wd1). Using multiepoch Hubble Space Telescope observations, we measure the proper motions of 10,346 stars and present an unprecedented determination of cluster
Lingfeng Wei, Peter C. Boyle, Jessica R. Lu, Matthew W. Hosek Jr., Quinn M. Konopacky, Richard G. Spencer, Dongwon Kim, Nicholas Z. Rui, Max Service, D. B. Huang, Jay Anderson   +10 more
doaj   +1 more source

Star Formation in the Dwarf Seyfert Galaxy NGC 4395: Evidence for Both AGN and SN Feedback? [PDF]

, 2023
Payel Nandi, C. S. Stalin, D. J. Saikia, S. Muneer, G. Mountrichas, Dominika Wylezalek, R. Sagar, M. Kissler‐Patig   +7 more
openalex   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Violent Starbursts and Quiescence Induced by Far-ultraviolet Radiation Feedback in Metal-poor Galaxies at High Redshift

The Astrophysical Journal
JWST observations of galaxies at z ≳ 8 suggest that they are more luminous and clumpier than predicted by most models, prompting several proposals on the physics of star formation and feedback in the first galaxies. In this paper, we focus on the role of
Kazuyuki Sugimura, Massimo Ricotti, Jongwon Park, Fred Angelo Batan Garcia, Hidenobu Yajima   +4 more
doaj   +1 more source