Results 131 to 140 of about 993,735 (252)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
Signatures of Mass Segregation from Competitive Accretion and Monolithic Collapse
The Astrophysical JournalThe two main competing theories proposed to explain the formation of massive (>10 M _⊙ ) stars—competitive accretion and monolithic core collapse—make different observable predictions for the environment of the massive stars during, and immediately after,
Richard J. Parker +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié +13 more
wiley +1 more source
Efficient semi-analytic modelling of Pop III star formation from Cosmic Dawn to Reionization
The Open Journal of AstrophysicsThe quest to find the first stars has driven astronomers across cosmic time, from hopes to identify their signatures in their heyday at cosmic dawn to deep searches for their remnants in our local neighborhood.
Sahil Hegde, Steven R. Furlanetto
doaj +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
A Tale of Three Tails: A Misaligned Streamer and Mysterious Structures around [BHB2007]-1
The Astrophysical JournalRecent discoveries of streamer-like structures around protostellar sources challenge the traditional picture of isolated, axisymmetric star formation. Here, we present new Atacama Large Millimeter/submillimeter Array observations of [BHB2007]-1, a flat ...
Aashish Gupta +10 more
doaj +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
A Tale of Three Dwarfs: Cluster-based Star Formation Histories of Blue Compact Dwarf Galaxies
The Astrophysical JournalWe present a new study of the cluster populations in the blue compact dwarf galaxies (BCD) ESO185-IG13, ESO338-IG04, and Haro11, based on new and archival high-resolution images taken by the Hubble Space Telescope, and the first to probe the populations ...
Rupali Chandar +11 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
The Astrophysical JournalWe study the kinematics of condensations in 30 fields forming high-mass stars with the Atacama Large Millimeter/submillimeter Array at a high resolution of $\sim 0\mathop{.}\limits{^{\prime\prime} }08$ on average (∼230 au).
Fernando A. Olguin +21 more
doaj +1 more source