Results 171 to 180 of about 976,493 (346)

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

open access: yesMolecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka   +10 more
wiley   +1 more source

Suppression of Star Formation in Galaxy Pairs

open access: yesThe Astrophysical Journal
We investigate the suppression of star formation in galaxy pairs based on the isolated galaxy pair sample derived from the Sloan Digital Sky Survey survey.
Shuai Feng   +5 more
doaj   +1 more source

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

open access: yesMolecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser   +11 more
wiley   +1 more source

Seeding Cores: A Pathway for Nuclear Star Clusters from Bound Star Clusters in the First Billion Years

open access: yesThe Open Journal of Astrophysics
We model the formation of star clusters in a dwarf galaxy progenitor during the first 700 Myr of cosmic history using a cosmological radiation-hydrodynamic simulation with a sub-grid star formation efficiency (SFE) model calibrated from AU-scale ...
Fred Angelo Batan Garcia   +2 more
doaj   +1 more source

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