Results 191 to 200 of about 5,183,495 (311)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Star formation shut down by multiphase gas outflow in a galaxy at a redshift of 2.45. [PDF]

Nature
Belli S, Park M, Davies RL, Mendel JT, Johnson BD, Conroy C, Benton C, Bugiani L, Emami R, Leja J, Li Y, Maheson G, Mathews EP, Naidu RP, Nelson EJ, Tacchella S, Terrazas BA, Weinberger R.   +17 more
europepmc   +1 more source

Astrochemical evolution along star formation: Overview of the IRAM Large Program ASAI. [PDF]

Mon Not R Astron Soc, 2018
Lefloch B, Bachiller R, Ceccarelli C, Cernicharo J, Codella C, Fuente A, Kahane C, López-Sepulcre A, Tafalla M, Vastel C, Caux E, González-García M, Bianchi E, Gómez-Ruiz A, Holdship J, Mendoza E, Ospina-Zamudio J, Podio L, Quénard D, Roueff E, Sakai N, Viti S, Yamamoto S, Yoshida K, Favre C, Monfredini T, Quitián-Lara HM, Marcelino N, Boechat-Roberty HM, Cabrit S.   +29 more
europepmc   +1 more source

The ALPINE-CRISTAL-JWST survey: spatially resolved star formation relations at $z\sim5$

C. Accard, M. Béthermin, M. Boquien, V. Buat, L. Vallini, F. Renaud, Katarina Kraljic, M. Aravena, P. Cassata, E. da Cunha, P. van Dam, I. de Looze, M. Dessauges‐Zavadsky, Yohan Dubois, A. Faisst, Y. Fudamoto, M. Ginolfi, C. Gruppioni, San Han, R. Herrera-Camus, H. Inami, A. M. Koekemoer, B. C. Lemaux, Juno Li, Yuan Li, B. Mobasher, Juan Carlos Molina, A. Nanni, Marco Palla, F. Pozzi, M. Relaño, Michael Romano, P. Sawant, Justin Spilker, Akiyoshi Tsujita, E. Veraldi, Vicente Villanueva, Wenxin Wang, S. K. Yi, G. Zamorani   +39 more
openalex   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

Molecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf, Daniel Ehinger, Hans Brunnström, Mats Jönsson, Frida Rosengren, Marija Kotevska, Anna Karlsson, Mattias Aine, Christian Frezza, Maria Planck, Elsa Arbajian   +10 more
wiley   +1 more source

The Little Engines That Could? Globular clusters contribute significantly to reionization-era star formation. [PDF]

Mon Not R Astron Soc, 2018
Boylan-Kolchin M.
europepmc   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

From the top down and back up again: star cluster structure from hierarchical star formation. [PDF]

Mon Not R Astron Soc, 2018
Grudić MY, Guszejnov D, Hopkins PF, Lamberts A, Boylan-Kolchin M, Murray N, Schmitz D.   +6 more
europepmc   +1 more source

The ACCEPTance of automation: refining circulating tumor cells enumeration for improved metastatic colorectal cancer prognosis

Molecular Oncology, EarlyView.
This study highlights the potential of automated enumeration using the ACCEPT software to refine circulating tumor cell (CTC) detection in metastatic colorectal cancer (mCRC). The automated method demonstrates improved accuracy and reduced variability compared to the manual approach.
Michela De Meo, Marco Siringo, Alessandro Vici, Ann Zeuner, Orietta Gandini, Paola Gazzaniga, Chiara Nicolazzo   +6 more
wiley   +1 more source

Planetary system, star formation, and black hole science with non-redundant masking on space telescopes [PDF]

, 2009
Anand Sivaramakrishnan, Peter Tuthill, Michael Ireland, James P. Lloyd, Marshall D. Perrin, Rémi Soummer, Barry McKernan, K. E. Saavik Ford   +7 more
openalex   +1 more source