Results 191 to 200 of about 202,775 (306)
Chemically-Deduced Star Formation Histories Of Dwarf Galaxies Using Barium
, 2017 G. Duggan, Evan N. Kirby
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STAR FORMATION IN THE EXTENDED GASEOUS DISK OF THE ISOLATED GALAXY CIG 96 [PDF]
, 2011 D. Espada +11 more
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Does the Fundamental Metallicity Relation Evolve with Redshift? I: The Correlation Between Offsets from the Mass-Metallicity Relation and Star Formation Rate [PDF]
Alex M. Garcia +10 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Statistics of A-Type Stars As Possible Indicator of Star Formation [PDF]
, 1984 L. G. Balázs
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Galaxy Pairs in cosmological simulations: Effects of interactions on\n star formation [PDF]
, 2005 M. Josefa Perez +3 more
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