Results 141 to 150 of about 332,346 (345)

An analysis of the isomers HCN and HNC in the evolution of high-mass star-forming regions [PDF]

, 2023
N. C. Martinez, S. Parón
openalex   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

The ALMA-ATOMS-QUARKS Survey: Resolving a Chemically Rich Massive Protostellar Outflow

The Astrophysical Journal
We present a comprehensive study on the physical and chemical structures of a chemically rich bipolar outflow in a high-mass star-forming region IRAS 16272−4837 (SDC335), utilizing high-resolution spectral line data at 1.3 and 3 mm dual bands from the ...
Jiahang Zou, Tie Liu, Fengwei Xu, Xindi Tang, Dezhao Meng, Yan-Kun Zhang, Aiyuan Yang, Tapas Baug, Chang-Won Lee, L. Viktor Tóth, Ariful Hoque, Sami Dib, Pablo Garcia, Hong-Li Liu, Prasanta Gorai, Swagat R. Das, Guido Garay, Patricio Sanhueza, Li Chen, Di Li, Jihye Hwang, Dongting Yang, The ATOMS-QUARKS collaboration   +22 more
doaj   +1 more source

EVN observations of 6.7 GHz methanol maser polarization in massive star-forming regions [PDF]

, 2019
G. Surcis, W. H. T. Vlemmings, Huib Jan van Langevelde, B. Hutawarakorn Kramer, A. Bartkiewicz   +4 more
openalex   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Can Clump Properties Determine Core Distribution in Star Formation? A Statistical Analysis of Magnetohydrodynamic Simulations

The Astrophysical Journal
Dense cores, the progenitors of stars, are in sub-pc scale and fragmented from pc-scale clumps. However, it is still unclear how strongly the fragmentation process is affected by the properties of the host clumps and how these properties influence the ...
Wei-An Chen, S. D. Clarke, Ya-Wen Tang
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Interstellar Glycolaldehyde, Methyl Formate, and Acetic Acid. I. A Bimodal Abundance Pattern in Star-forming Regions [PDF]

, 2019
Samer J. El-Abd, Crystal L. Brogan, Todd R. Hunter, Eric R. Willis, Robin T. Garrod, Brett A. McGuire   +5 more
openalex   +1 more source

Carbonates and ices in the z = 0.89 galaxy-absorber towards PKS 1830–211 and within star-forming regions of the Milky Way [PDF]

, 2023
J. E. Bowey
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source