Results 131 to 140 of about 288,104 (243)

Can Clump Properties Determine Core Distribution in Star Formation? A Statistical Analysis of Magnetohydrodynamic Simulations

The Astrophysical Journal
Dense cores, the progenitors of stars, are in sub-pc scale and fragmented from pc-scale clumps. However, it is still unclear how strongly the fragmentation process is affected by the properties of the host clumps and how these properties influence the ...
Wei-An Chen, S. D. Clarke, Ya-Wen Tang
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

The ALMA-ATOMS-QUARKS Survey: Resolving a Chemically Rich Massive Protostellar Outflow

The Astrophysical Journal
We present a comprehensive study on the physical and chemical structures of a chemically rich bipolar outflow in a high-mass star-forming region IRAS 16272−4837 (SDC335), utilizing high-resolution spectral line data at 1.3 and 3 mm dual bands from the ...
Jiahang Zou, Tie Liu, Fengwei Xu, Xindi Tang, Dezhao Meng, Yan-Kun Zhang, Aiyuan Yang, Tapas Baug, Chang Won Lee, L. Viktor Tóth, Ariful Hoque, Sami Dib, Pablo Garcia, Hong-Li Liu, Prasanta Gorai, Swagat R. Das, Guido Garay, Patricio Sanhueza, Li Chen, Di Li, Jihye Hwang, Dongting Yang   +21 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Investigating the Star-forming Sites in the Outer Galactic Arm

The Astronomical Journal
We aim to investigate the global star formation scenario in star-forming sites AFGL 5157, [FSR2007] 0807 (hereafter FSR0807), [HKS2019] E70 (hereafter E70), [KPS2012] MWSC 0620 (hereafter KPS0620), and IRAS 05331+3115 in the outer Galactic arm.
Aayushi Verma, Saurabh Sharma, Lokesh K. Dewangan, Devendra K. Ojha, Kshitiz Mallick, Ram Kesh Yadav, Harmeen Kaur, Tarak Chand, Mamta, Archana Gupta   +9 more
doaj   +1 more source

Distances to star forming regions

, 2014
The determination of accurate distances to star-forming regions are discussed in the broader historical context of astronomical distance measurements. We summarize recent results for regions within 1 kpc and present perspectives for the near and more distance future.
openaire   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Magnetic Field Alignment Relative to Multiple Tracers in the High-mass Star-forming Region RCW 36

The Astrophysical Journal
We use polarization data from SOFIA HAWC+ to investigate the interplay between magnetic fields and stellar feedback in altering gas dynamics within the high-mass star-forming region RCW 36, located in Vela C.
Akanksha Bij, Laura M. Fissel, Lars Bonne, Nicola Schneider, Marc Berthoud, Dennis Lee, Giles A. Novak, Sarah I. Sadavoy, Thushara G. S. Pillai, Maria Cunningham, Paul Jones, Robert Simon   +11 more
doaj   +1 more source