Results 111 to 120 of about 3,871,291 (295)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

JWST’s First View of the Most Vigorously Star-forming Cloud in the Galactic Center: Sagittarius B2

The Astronomical Journal
We report JWST NIRCAM and MIRI observations of Sgr B2, one of the most active sites of star formation in the Galaxy. These observations, using 14 filters spanning 1.5–25 μ m, have revealed a multilayered and highly structured cloud that contains both a ...
Nazar Budaiev, Adam Ginsburg, Ashley T. Barnes, Desmond Jeff, Taehwa Yoo, Cara Battersby, Alyssa Bulatek, Savannah Gramze, Xing Lu, Elisabeth A. C. Mills, Theo Richardson, Daniel L. Walker   +11 more
doaj   +1 more source

Star Forming Regions in Cepheus

, 2008
104 pages, 25 tables, 35 figures; A chapter in the "Handbook of Star Forming Regions, Vol 1: The Northern Sky," ed. Bo Reipurth; ASP Monograph Series. Full resolution version can be found at http://www.konkoly.hu/staff/kun/handbook_chapters/
Kun, M., Kiss, Z. T., Balog, Z.
openaire   +2 more sources

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

: A new UV-millimeter emission library for star-forming regions

Context. The current generation galaxy formation simulations often approximate star formation, making it necessary to use models of star-forming regions to produce observables from such simulations.
Camps, Peter, Vicens, Sebastien, Nick Andreadis, Gebek, Andrea, Kapoor, Anand Utsav, Arjen van der Wel, Boquien, Médéric, Maarten Baes, Médéric Boquien, Andrea Gebek, Sebastien Vicens, Andreadis, Nick, Peter Camps, Smith, Aaron, Aaron Smith, van der Wel, Arjen, Anand Utsav Kapoor, Baes, Maarten   +17 more
core   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Giant star-forming regions in interacting galaxies [PDF]

The most violent processes of star formation can be found in interacting galaxies, where gas compression can trigger the formation of giant star-forming regions. Using high-resolution spectroscopic information from MIKE/Magellan and multi- slit data from
Bosch, Guillermo Luis, Campuzano Castro, Federico, Hägele, Guillermo Federico, Firpo, Verónica, Torres-Flores, Sergio   +4 more
core  

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source