Results 111 to 120 of about 47,546 (266)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Investigating the Influence of Radiative Feedback in the Bright-rimmed Cloud 44

The Astrophysical Journal
Radiative feedback from massive stars plays a central role in the evolution of molecular clouds and the interstellar medium. This paper presents a multiwavelength analysis of the bright-rimmed cloud (BRC) 44, which is located at the periphery of the H ii
Rishi C, Neelam Panwar, Thomas J. Haworth, Yan Sun, Saurabh Sharma, R. K. Yadav, D.K. Ojha, H.P. Singh, Jessy Jose, Ajay Kumar Singh, Jincen Jose, Shubham Yadav   +11 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Young Stellar Objects in the Massive Star-forming Regions W51 and W43. [PDF]

Astrophys J, 2017
Saral G, Hora JL, Audard M, Koenig XP, Martínez-Galarza JR, Motte F, Nguyen-Luong Q, Saygac AT, Smith HA.   +8 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

FEAST: JWST Uncovers the Emerging Timescales of Young Star Clusters in M83

The Astrophysical Journal
We present JWST NIRCam observations of the emerging young star clusters (eYSCs) detected in the nearby spiral galaxy M83. The NIRcam mosaic encompasses the nuclear starburst, the bar, and the inner spiral arms.
Alice Knutas, Angela Adamo, Alex Pedrini, Sean T. Linden, Varun Bajaj, Jenna E. Ryon, Benjamin Gregg, Ahmad A. Ali, Eric P. Andersson, Arjan Bik, Giacomo Bortolini, Anne S. M. Buckner, Daniela Calzetti, Ana Duarte-Cabral, Bruce G. Elmegreen, Helena Faustino Vieira, John S. Gallagher, Kathryn Grasha, Kelsey Johnson, Thomas S.-Y. Lai, Drew Lapeer, Matteo Messa, Göran Östlin, Elena Sabbi, Linda J. Smith, Monica Tosi   +25 more
doaj   +1 more source

Structure of photodissociation fronts in star-forming regions revealed by observations of high-J CO emission lines with Herschel. [PDF]

Astron Astrophys, 2018
Joblin C, Bron E, Pinto C, Pilleri P, Le Petit F, Gerin M, Le Bourlot J, Fuente A, Berne O, Goicoechea JR, Habart E, Köhler M, Teyssier D, Nagy Z, Montillaud J, Vastel C, Cernicharo J, Röllig M, Ossenkopf-Okada V, Bergin EA.   +19 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

VLA 22 GHz Imaging of Massive Star Formation in Local Wolf–Rayet Galaxies

The Astrophysical Journal
We present 22 GHz imaging of regions of massive star formation within the Local Wolf–Rayet Galaxy Sample, a NSF Karl G. Jansky Very Large Array survey of 30 local galaxies showing spectral features of Wolf–Rayet (WR) stars.
Nicholas G. Ferraro, Jean L. Turner, Sara C. Beck, Edwin Alexani, Runa Indrei, Bethany M. Welch, Tunhui Xie   +6 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source