Results 101 to 110 of about 288,104 (243)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

JWST-FEAST: Feedback in Emerging extrAgalactic Star clusTers: Calibration of Star Formation Rates in the Mid-infrared with NGC 628

The Astrophysical Journal
New JWST near-infrared imaging of the nearby galaxy NGC 628 from the JWST Cycle 1 program Feedback in Emerging extrAgalactic Star clusTers (JWST-FEAST) is combined with archival JWST mid-infrared imaging to calibrate the 21 μ m emission as a star ...
Daniela Calzetti, Angela Adamo, Sean T. Linden, Benjamin Gregg, Mark R. Krumholz, Varun Bajaj, Arjan Bik, Michele Cignoni, Matteo Correnti, Bruce Elmegreen, Helena Faustino Vieira, John S. Gallagher, Kathryn Grasha, Robert A. Gutermuth, Kelsey E. Johnson, Matteo Messa, Jens Melinder, Göran Östlin, Alex Pedrini, Elena Sabbi, Linda J. Smith, Monica Tosi   +21 more
doaj   +1 more source

The Orion Star-Forming Region

, 2000
General properties of the Orion star-forming region are discussed, with a focus on the dense Orion Nebula Cluster (ONC). This cluster contains between 2500 and 4500 objects located within a few parsecs of the eponymous Trapezium stars. Its members are aged <1 to a few Myr and encompass the full spectrum of stellar masses <50 Msun, as well as ...
Hillenbrand, Lynne A., Carpenter, John M., Feigelson, Eric D.   +2 more
openaire   +2 more sources

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

ALMA-IMF. XIV. Free–Free Templates Derived from H41α and Ionized Gas Content in 15 Massive Protoclusters

The Astrophysical Journal Supplement Series
We use the H41 α recombination line to create templates of the millimeter free–free emission in the ALMA-IMF continuum maps, which allows us to separate it from dust emission.
Roberto Galván-Madrid, Daniel J. Díaz-González, Frédérique Motte, Adam Ginsburg, Nichol Cunningham, Karl M. Menten, Mélanie Armante, Mélisse Bonfand, Jonathan Braine, Timea Csengeri, Pierre Dell’Ova, Fabien Louvet, Thomas Nony, Rudy Rivera-Soto, Patricio Sanhueza, Amelia M. Stutz, Friedrich Wyrowski, Rodrigo H. Álvarez-Gutiérrez, Tapas Baug, Sylvain Bontemps, Leonardo Bronfman, Manuel Fernández-López, Antoine Gusdorf, Atanu Koley, Hong-Li Liu, Javiera Salinas, Allison P. M. Towner, Anthony P. Whitworth   +27 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Different Influence of Gas Accretion on the Evolution of Star-forming and Non-star-forming Galaxies

The Astrophysical Journal
Using integral field spectroscopic data from the Mapping Nearby Galaxies at Apache Point Observatory survey, we investigate the spatially resolved properties and empirical relations of a star-forming galaxy and a non-star-forming galaxy hosting ...
Min Bao, Wenlong Zhao, Qirong Yuan
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source