Results 101 to 110 of about 47,546 (266)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Metal-poor Gas Accretion Drives Giant Clump Formation at 0.6 < z < 2.6

The Astrophysical Journal
The physical properties of kiloparsec-scale clumps in high-redshift star-forming galaxies (SFGs) contain crucial constraints on how they assemble. Building on recent work that indicates the presence of a metallicity offset in clumpy galaxies compared to ...
Visal Sok, Adam Muzzin, Ben Forrest, Gillian Wilson, Jialu Chen, Vivian Yun Yan Tan, Sunna Withers, Roberto Abraham, Maruša Bradač, Vicente Estrada-Carpenter, Kartheik G. Iyer, Nicholas S. Martis, Gaël Noirot, Ghassan T. E. Sarrouh, Marcin Sawicki, Chris J. Willott, Aurélien Henry, Naadiyah Jagga, Danilo Marchesini, Ian McConachie, Katherine Myers, Nelson Nunes, Luke Robbins   +22 more
doaj   +1 more source

Molecular gas and star formation in GASP jellyfish galaxies

Astronomy & Astrophysics
Context. Several studies have reported a nearly linear correlation between the molecular gas and star formation rate surface density, the so-called Kennicutt-Schmidt (KS) law. Aims.
Moretti A., Paladino R., Bacchini C., Marasco A., Giunchi E., Poggianti B. M., Hunt L. K., Deb T., Vulcani B., Gullieuszik M., Lassen A., Wolter A., Gitti M., Radovich M., Fritz J., Tomicic N.   +15 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Large-scale Mapping Observations of DCN and DCO+ toward Orion KL

The Astrophysical Journal
We present emission maps ( $1\buildrel{\,\prime}\over{.} 5\,\times \,1\buildrel{\,\prime}\over{.} 5$ scale, corresponding to 0.18 pc) of the DCN ( J = 2 − 1) and DCO ^+ ( J = 2 − 1) lines in the 2 mm band toward the Orion KL region obtained with the 2 mm
Kotomi Taniguchi, Prathap Rayalacheruvu, Teppei Yonetsu, Tatsuya Takekoshi, Bunyo Hatsukade, Kotaro Kohno, Tai Oshima, Yoichi Tamura, Yuki Yoshimura, Víctor Gómez-Rivera, Sergio Rojas-García, Arturo I. Gómez-Ruiz, David H. Hughes, F. Peter Schloerb, Liton Majumdar, Masao Saito, Iván Rodríguez-Montoya, David Sánchez-Arguelles, Ryohei Kawabe   +18 more
doaj   +1 more source

The Orion Star Forming Region

, 2018
Talk given at Walk the Line ...
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Low-mass Stellar and Substellar Content of the Young Cluster Berkeley 59

The Astronomical Journal
We present a multiwavelength analysis of the young star cluster Berkeley 59, based on Gaia data and deep IR observations with the 3.58 m Telescopio Nazionale Galileo and Spitzer space telescope.
Neelam Panwar, Rishi C., Saurabh Sharma, Devendra K. Ojha, Manash R. Samal, H. P. Singh, Ram Kesh Yadav   +6 more
doaj   +1 more source

Zeeman effect in sulfur monoxide: A tool to probe magnetic fields in star forming regions. [PDF]

Astron Astrophys, 2017
Cazzoli G, Lattanzi V, Coriani S, Gauss J, Codella C, Ramos AA, Cernicharo J, Puzzarini C.   +7 more
europepmc   +1 more source