Results 81 to 90 of about 47,546 (266)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Global and Local Infall in the ASHES Sample (GLASHES). II. Asymmetric Line Profiles Around Dense Cores in 70 μm Dark Massive Clumps

The Astrophysical Journal
Gravitational collapse is fundamental to star formation, yet direct kinematic evidence of infall at the core scale in high-mass star-forming regions remains poorly constrained.
Kaho Morii, Patricio Sanhueza, Qizhou Zhang, James M. Jackson   +3 more
doaj   +1 more source

NO molecule in massive star-forming regions

Astronomy & Astrophysics
Context. CN, CO, and NO are diatomic molecules composed of the abundant elements C, N, and O. NO has been detected far less extensively than the well-studied CN and CO, remaining a crucial yet under-observed component in N-containing chemical networks ...
Su Shaomin, Wang Junzhi, Luo Rui, Xu Yani, Mo Fu, Liu Yijia, Ruan Chang, Kang Yingxue, Li Yuqiang, Zheng Siqi   +9 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

JWST-FEAST: Feedback in Emerging extrAgalactic Star clusTers: Calibration of Star Formation Rates in the Mid-infrared with NGC 628

The Astrophysical Journal
New JWST near-infrared imaging of the nearby galaxy NGC 628 from the JWST Cycle 1 program Feedback in Emerging extrAgalactic Star clusTers (JWST-FEAST) is combined with archival JWST mid-infrared imaging to calibrate the 21 μ m emission as a star ...
Daniela Calzetti, Angela Adamo, Sean T. Linden, Benjamin Gregg, Mark R. Krumholz, Varun Bajaj, Arjan Bik, Michele Cignoni, Matteo Correnti, Bruce Elmegreen, Helena Faustino Vieira, John S. Gallagher, Kathryn Grasha, Robert A. Gutermuth, Kelsey E. Johnson, Matteo Messa, Jens Melinder, Göran Östlin, Alex Pedrini, Elena Sabbi, Linda J. Smith, Monica Tosi   +21 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

ALMA-IMF. XIV. Free–Free Templates Derived from H41α and Ionized Gas Content in 15 Massive Protoclusters

The Astrophysical Journal Supplement Series
We use the H41 α recombination line to create templates of the millimeter free–free emission in the ALMA-IMF continuum maps, which allows us to separate it from dust emission.
Roberto Galván-Madrid, Daniel J. Díaz-González, Frédérique Motte, Adam Ginsburg, Nichol Cunningham, Karl M. Menten, Mélanie Armante, Mélisse Bonfand, Jonathan Braine, Timea Csengeri, Pierre Dell’Ova, Fabien Louvet, Thomas Nony, Rudy Rivera-Soto, Patricio Sanhueza, Amelia M. Stutz, Friedrich Wyrowski, Rodrigo H. Álvarez-Gutiérrez, Tapas Baug, Sylvain Bontemps, Leonardo Bronfman, Manuel Fernández-López, Antoine Gusdorf, Atanu Koley, Hong-Li Liu, Javiera Salinas, Allison P. M. Towner, Anthony P. Whitworth   +27 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

JWST’s First View of the Most Vigorously Star-forming Cloud in the Galactic Center: Sagittarius B2

The Astronomical Journal
We report JWST NIRCAM and MIRI observations of Sgr B2, one of the most active sites of star formation in the Galaxy. These observations, using 14 filters spanning 1.5–25 μ m, have revealed a multilayered and highly structured cloud that contains both a ...
Nazar Budaiev, Adam Ginsburg, Ashley T. Barnes, Desmond Jeff, Taehwa Yoo, Cara Battersby, Alyssa Bulatek, Savannah Gramze, Xing Lu, Elisabeth A. C. Mills, Theo Richardson, Daniel L. Walker   +11 more
doaj   +1 more source