Results 71 to 80 of about 47,546 (266)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Global and Local Infall in the ASHES Sample (GLASHES). I. Pilot Study in G337.541

The Astrophysical Journal
Recent high-angular-resolution observations indicate the need for core growth to form high-mass stars. To understand the gas dynamics at the core scale in the very early evolutionary stages before being severely affected by feedback, we have conducted ...
Kaho Morii, Patricio Sanhueza, Timea Csengeri, Fumitaka Nakamura, Sylvain Bontemps, Guido Garay, Qizhou Zhang   +6 more
doaj   +1 more source

The Orion Star-Forming Region

, 2000
General properties of the Orion star-forming region are discussed, with a focus on the dense Orion Nebula Cluster (ONC). This cluster contains between 2500 and 4500 objects located within a few parsecs of the eponymous Trapezium stars. Its members are aged <1 to a few Myr and encompass the full spectrum of stellar masses <50 Msun, as well as ...
Hillenbrand, Lynne A., Carpenter, John M., Feigelson, Eric D.   +2 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Tracking Star-forming Cores as Mass Reservoirs in Clustered and Isolated Regions Using Numerical Passive Tracer Particles

The Astrophysical Journal
Understanding the physical properties of star-forming cores as mass reservoirs for protostars and the impact of turbulence is crucial in star formation studies.
Shingo Nozaki, Hajime Fukushima, Kazuki Tokuda, Masahiro N. Machida   +3 more
doaj   +1 more source

Protostellar Feedback in Massive Star Forming Regions

, 2023
We examine mechanical feedback mechanisms during the protostellar phase through jets and outflows. To do so, we make use of velocity-resolved CII observations at 158 $\mu$m taken with the SOFIA observatory. We identify CII emitting cavities at velocities ranging from 1-2 km s$^{-1}$ to 15 km s$^{-1}$ relative to the Veil shell ($v_\mathrm{LSR}$ = 13 km
Kavak, U., Bally, J., Goicoechea, J., Tak, F. van der, Tielens, A.G.G.M.   +4 more
openaire   +3 more sources

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The Milky Way Project: Bridging Intermediate- and High-mass Star Formation with the MIRION Catalog of Yellowballs

The Astrophysical Journal
We describe the construction and use of the Mid-InfraRed Interstellar Objects and Nebulae (MIRION) catalog, which was compiled from 6176 objects identified as “yellowballs” (YBs) by participants in the Milky Way Project.
Kathryn Devine, Grace Wolf-Chase, C. R. Kerton, Nicholas Larose, Maya Coleman, Makenzie Stapley, Ethan Bassingthwaite, Bezawit Mekasha Kassaye, Hritik Rawat, Tharindu Jayasinghe   +9 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dense Cores in IRDC G14.225-0.506 Revealed by ALMA Observations

The Astrophysical Journal
Dense cores in massive, parsec-scale molecular clumps are sites that harbor protocluster formation. We present results from observations toward a hub–filament structure of a massive infrared (IR) dark cloud G14.225-0.506 using the Atacama Large ...
Yanhanle Zhao, Qizhou Zhang, Junhao Liu, Xing Pan, Lingzhen Zeng   +4 more
doaj   +1 more source