Results 141 to 150 of about 288,104 (243)

Protostellar Feedback in Massive Star Forming Regions

, 2023
We examine mechanical feedback mechanisms during the protostellar phase through jets and outflows. To do so, we make use of velocity-resolved CII observations at 158 $\mu$m taken with the SOFIA observatory. We identify CII emitting cavities at velocities ranging from 1-2 km s$^{-1}$ to 15 km s$^{-1}$ relative to the Veil shell ($v_\mathrm{LSR}$ = 13 km
Kavak, U., Bally, J., Goicoechea, J., Tak, F. van der, Tielens, A.G.G.M.   +4 more
openaire   +3 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Digging Into the Interior of Hot Cores with ALMA (DIHCA). V. Deuterium Fractionation of Methanol

The Astrophysical Journal
We have observed the ^13 CH _3 OH 5 _1 −4 _1 A ^+ , ^13 CH _3 OH 14 _1 −13 _2 A ^− , and CH _2 DOH 8 _2,6 −8 _1,7 e _0 lines toward 24 high-mass star-forming regions by using Atacama Large Millimeter/submillimeter Array with an angular resolution of ...
Takeshi Sakai, Nobuhito Shiomura, Patricio Sanhueza, Kenji Furuya, Fernando A. Olguin, Ken’ichi Tatematsu, Yuri Aikawa, Kotomi Taniguchi, Huei-Ru Vivien Chen, Kaho Morii, Fumitaka Nakamura, Shanghuo Li, Xing Lu, Qizhou Zhang, Tomoya Hirota, Kousuke Ishihara, Hongda Ke, Nami Sakai, Satoshi Yamamoto   +18 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Planet Formation Regulated by Galactic-scale Interstellar Turbulence

The Astrophysical Journal Letters
Planet formation occurs over a few Myr within protoplanetary disks of dust and gas, which are often assumed to evolve in isolation. However, extended gaseous structures have been uncovered around many protoplanetary disks, suggestive of late-stage infall
Andrew J. Winter, Myriam Benisty, Sean M. Andrews   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

B-fields and Dust in Interstellar Filaments Using Dust Polarization (BALLAD-POL). II. Testing the Radiative Torque Paradigm in Musca and OMC-1

The Astrophysical Journal
Polarization of starlight and thermal dust emission caused by aligned dust grains is a valuable tool to characterize magnetic fields ( B -fields) and constrain dust properties. However, the grain alignment physics is not fully understood.
Nguyen Bich Ngoc, Thiem Hoang, Pham Ngoc Diep, Le Ngoc Tram   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source