Results 161 to 170 of about 318,054 (345)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Unveiling Physical Conditions and Star Formation Processes in the G47 Filamentary Cloud

The Astrophysical Journal
We present a multiwavelength study of the filamentary cloud G47 ( d ∼ 4.44 kpc), which hosts the mid-infrared bubbles N98, B1, and B2. The SMGPS 1.3 GHz continuum map detects ionized emission toward all the bubbles, marking the first detection of ionized
O. R. Jadhav, L. K. Dewangan, A. Haj Ismail, N. K. Bhadari, A. K. Maity, Ram Kesh Yadav, Moustafa Salouci, Patricio Sanhueza, Saurabh Sharma   +8 more
doaj   +1 more source

Zeeman effect in sulfur monoxide: A tool to probe magnetic fields in star forming regions. [PDF]

Astron Astrophys, 2017
Cazzoli G, Lattanzi V, Coriani S, Gauss J, Codella C, Ramos AA, Cernicharo J, Puzzarini C.   +7 more
europepmc   +1 more source

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Young Stellar Objects in the Massive Star-forming Regions W51 and W43. [PDF]

Astrophys J, 2017
Saral G, Hora JL, Audard M, Koenig XP, Martínez-Galarza JR, Motte F, Nguyen-Luong Q, Saygac AT, Smith HA.   +8 more
europepmc   +1 more source

[ITAL]HUBBLE SPACE TELESCOPE[/ITAL][ITAL]Hubble Space Telescope[/ITAL] Observations of Dust and Star-forming Regions in the Ocular Galaxy IC 2163 and Its Spiral Companion NGC 2207 [PDF]

, 2001
D. M. Elmegreen, Michele Kaufman, Bruce G. Elmegreen, E. Brinks, Curtis Struck, Mario Klarić, M. Thomasson   +6 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Interferometric Mapping of Magnetic Fields in Star‐forming Regions. I. W51 e1/e2 Molecular Cores [PDF]

, 2001
S. Lai, R. M. Crutcher, J. M. Girart, Ramprasad Rao   +3 more
openalex   +1 more source

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

Gravitationally Induced Explosive Outflows

The Astrophysical Journal
Over the past decade, there has been a significant increase in the reporting of extensive and luminous star-forming regions associated with explosive outflows.
P. R. Rivera-Ortiz, A. Rodríguez-González, J. Cantó, L. A. Zapata, L. Hernández-Martínez, E. Guzmán Ccolque, M. Fernández-López   +6 more
doaj   +1 more source