Results 51 to 60 of about 563,924 (339)

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

Star Formation and Molecular Gas Diagnostics with Mid- and Far-infrared Emission

The Astrophysical Journal, 2023
With the start of JWST observations, mid-infrared (MIR) emission features from polycyclic aromatic hydrocarbons (PAHs), H _2 rotational lines, fine structure lines from ions, and dust continuum will be widely available tracers of gas and star formation ...
C. M. Whitcomb, K. Sandstrom, A. Leroy, J.-D. T. Smith   +3 more
doaj   +1 more source

Star Formation Efficiency in the Central 1 kpc Region of Early-Type Spiral Galaxies [PDF]

, 2000
It has been reported recently that there are some early-type spiral (Sa--Sab) galaxies having evident star-forming regions which concentrate in their own central 1-kpc. In such central region, is the mechanism of the star formation distinct from that in disks of spiral galaxies?
arxiv   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Thermal Effects of Ambipolar Diffusion during the Gravitational Collapse of a Radiative Cooling Filament

The Astrophysical Journal
In this study, we consider the effects of ambipolar diffusion during the gravitational collapse of a radiative cooling filamentary molecular cloud. Two separate configurations of magnetic field, i.e., axial and toroidal, are considered in the presence of
Mahmoud Gholipour
doaj   +1 more source

Unusually Powerful Flare Phenomenon of the Water Maser in W51 and the Possibility of Detecting Gravitational Radiation from It

The Astrophysical Journal, 2023
Because of detailed monitoring of the 22.2 GHz water maser, carried out from 2021 October to 2023 May, a very powerful flare phenomenon was detected in the galactic object W51 near the radial velocity of 60 km s ^−1 with the amplitude of 140 kJy.
A. E. Volvach, L. N. Volvach, M. G. Larionov   +2 more
doaj   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

The ALMA Survey of 70 μm Dark High-mass Clumps in Early Stages (ASHES). IX. Physical Properties and Spatial Distribution of Cores in IRDCs

The Astrophysical Journal, 2023
The initial conditions found in infrared dark clouds (IRDCs) provide insights on how high-mass stars and stellar clusters form. We have conducted high-angular resolution and high-sensitivity observations toward thirty-nine massive IRDC clumps, which have
Kaho Morii, Patricio Sanhueza, Fumitaka Nakamura, Qizhou Zhang, Giovanni Sabatini, Henrik Beuther, Xing Lu, Shanghuo Li, Guido Garay, James M. Jackson, Fernando A. Olguin, Daniel Tafoya, Ken’ichi Tatematsu, Natsuko Izumi, Takeshi Sakai, Andrea Silva   +15 more
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

The Star Forming Regions of Orion [PDF]

International Astronomical Union Colloquium, 1995
AbstractThe distribution of emission line stars in Orion is presented, based on our recent surveys and other previous ones. Particular attention is given for the central 10 × 10 square degrees to compare some properties of emission line stars and OB association stars. As a result, a possibility of bimodal star formation is suggested in this region.
openaire   +2 more sources