Results 71 to 80 of about 44,874 (266)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Structure and Dynamics of the Young Massive Star Cluster Westerlund 1

The Astrophysical Journal
We present a structural and dynamical analysis of the young massive star cluster Westerlund 1 (Wd1). Using multiepoch Hubble Space Telescope observations, we measure the proper motions of 10,346 stars and present an unprecedented determination of cluster
Lingfeng Wei, Peter C. Boyle, Jessica R. Lu, Matthew W. Hosek Jr., Quinn M. Konopacky, Richard G. Spencer, Dongwon Kim, Nicholas Z. Rui, Max Service, D. B. Huang, Jay Anderson   +10 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

The Orion Star-Forming Region

, 2000
General properties of the Orion star-forming region are discussed, with a focus on the dense Orion Nebula Cluster (ONC). This cluster contains between 2500 and 4500 objects located within a few parsecs of the eponymous Trapezium stars. Its members are aged <1 to a few Myr and encompass the full spectrum of stellar masses <50 Msun, as well as ...
Hillenbrand, Lynne A., Carpenter, John M., Feigelson, Eric D.   +2 more
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

A JWST NIRCam/MIRI View of the W51A High-mass Star-forming Region

The Astronomical Journal
We present observations of the W51A region, including the massive protoclusters W51-E and W51-IRS2, with JWST in 10 NIRCam and 5 MIRI filters. In this work, we highlight the most novel features apparent in these images and compare them with other ...
Taehwa Yoo, Adam Ginsburg, Nazar Budaiev, Roberto Galván-Madrid, Aden Dawson, Savannah Gramze, Jesús Hernández, Alexandre Roman-Lopes, Carlos G. Román-Zúñiga, Joel Sanchez-Bermudez, Miriam G. Santa-Maria, Aida Wofford, Jason E. Ybarra   +12 more
doaj   +1 more source

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Global and Local Infall in the ASHES Sample (GLASHES). I. Pilot Study in G337.541

The Astrophysical Journal
Recent high-angular-resolution observations indicate the need for core growth to form high-mass stars. To understand the gas dynamics at the core scale in the very early evolutionary stages before being severely affected by feedback, we have conducted ...
Kaho Morii, Patricio Sanhueza, Timea Csengeri, Fumitaka Nakamura, Sylvain Bontemps, Guido Garay, Qizhou Zhang   +6 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Tracking Star-forming Cores as Mass Reservoirs in Clustered and Isolated Regions Using Numerical Passive Tracer Particles

The Astrophysical Journal
Understanding the physical properties of star-forming cores as mass reservoirs for protostars and the impact of turbulence is crucial in star formation studies.
Shingo Nozaki, Hajime Fukushima, Kazuki Tokuda, Masahiro N. Machida   +3 more
doaj   +1 more source