Results 101 to 110 of about 221,937 (281)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Fundamental Parameters of Hot Subdwarf Stars from Gaia Astrometry

, 2019
Asteroseismic modeling of pulsating hot subdwarf stars (sdBs/sdOs) and the investigation of eclipsing hot subdwarf binaries with low-mass or substellar companions (HW Vir systems) have contributed significantly to the list of sdBs/sdOs with known stellar
Irrgang, Andreas (7398329), Heber, Ulrich, Geier, Stephan (6485987), Latour, Marilyn, Schneider, David, Latour, Marilyn (5826920), Geier, Stephan, Heber, Ulrich (5926199), Schneider, David (7398326), Irrgang, Andreas   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

X-Shooting ULLYSES: Massive Stars at Low Metallicity X. Physical Parameters and Feedback of Massive Stars in the LMC N11 B Star-Forming Region

Massive stars drive the ionization and mechanical feedback within young star-forming regions. The Large Magellanic Cloud (LMC) is an ideal galaxy for studying individual massive stars and quantifying their feedback contribution to the environment.
A. A. C. Sander, Bernini-Peron, M., Gormaz-Matamala, A.C., Kehrig, C., L. M. Oskinova, N. Morrell, D. Pauli, Todt, H., Vink, J.S., Gormaz-Matamala, A. C., O. G. Telford, A. Wofford, Shenar, T., A. Mehner, Crowther, P.A., J. S. Vink, T. Shenar, V. Ramachandran, W.-R. Hamann, Sander, A. A.C., S. R. Berlanas, van Loon, J. Th, McLeod, A. F., Telford, O. G., S. Reyero Serantes, Hamann, W. R., Mahy, L., Crowther, P. A., Kuiper, R., Vink, J. S., F. Tramper, Sander, A.C., Telford, O.G., Pauli, D., P. A. Crowther, Reyero Serantes, S., ud-Doula, A., Berlanas, S. R., H. Todt, Ramachandran, V., Leitherer, C., Tramper, F., Wofford, A., A. F. McLeod, V. M. A. Gómez-González, C. Leitherer, Gómez-González, V.M.A., Mehner, A., Oskinova, L. M., J. Th. van Loon, R. Kuiper, Gómez-González, V. M.A., Th. van Loon, J., Berlanas, S.R., Oskinova, L.M., A. ud-Doula, A. C. Gormaz-Matamala, C. Kehrig, McLeod, A.F., M. Bernini-Peron, L. Mahy, Morrell, N.   +61 more
core   +1 more source

“X-Raying” a Be Star Disk: Fundamental Parameters of the Eclipsing Binary Be Star V658 Car

The Astrophysical Journal
Abstract With its two stellar eclipses and two disk attenuations per binary orbit, V658 Carinae stands out as the first clear eclipsing Be + sdOB system. This rare alignment offers a unique opportunity to probe the structure and dynamics of a Be star disk with unprecedented detail.
de Amorim, TH, Carciofi, AC, Labadie-Bartz, J, Silva, AC, Navarete, F, Rappaport, SA, Querido, P, Rubio, AC, Bjorkman, J, Gagliano, R, Terentev, I   +10 more
openaire   +5 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Chemical composition and fundamental parameters of roAp stars

, 1998
5 pages, 2 figures (the first being in fact a table), to appear in: Proc. of the 26th workshop of the European Working Group on CP stars, eds. P. North, A. Schnell and J. Ziznovsky, Contrib. Astr. Obs. Skalnate Pleso Vol.
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source