Results 111 to 120 of about 221,937 (281)

Fundamental oscillation modes of self-interacting bosonic dark stars

, 2020
We perform a detailed analysis of the fundamental f-mode frequencies and damping times of nonrotating stellar-mass boson stars in general relativity by solving the nonradial perturbation equations.
Flores, C. Vasquez;Parisi, Alessandro;Chen, Chian-Shu;Lugones, German
core   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Benchmark stars for mean stellar density and surface gravity estimates of solar-type stars

Adding an independent estimate of the mean stellar density, , as a constraint in the analysis of stars that host transiting exoplanets can significantly improve the precision of the planet radius estimate in cases where the light curve is too noisy to ...
Maxted, P F L
core   +1 more source

Symmetry in fundamental parameters of galaxies on the star-forming main sequence

Monthly Notices of the Royal Astronomical Society
ABSTRACT The Star-Forming Main Sequence (SFMS) serves as a critical framework for understanding galaxy evolution, highlighting the relationship between star formation rates (SFR) and stellar masses $M_*$ across cosmic time, for star forming galaxies.
Zhicheng He, Enci Wang, Luis C Ho, Huiyuan Wang, Yong Shi, Xu Kong, Tinggui Wang   +6 more
openaire   +2 more sources

The Fundamental Stellar Parameters of FGK Stars in the SEEDS Survey

, 2017
Large exoplanet surveys have successfully detected thousands of exoplanets to-date. Utilizing these detections and non-detections to constrain our understanding of the formation and evolution of planetary systems also requires a detailed understanding of the basic properties of their host stars.
Rich, Evan A., Wisniewski, John P., McElwain, Michael W., Hashimoto, Jun, Kudo, Tomoyuki, Kusakabe, Nobuhiko, Okamoto, Yoshiko K., Abe, Lyu, Akiyama, Eiji, Brandner, Wolfgang, Brandt, Timothy D., Cargile, Phillip, Carson, Joseph C., Currie, Thayne M, Egner, Sebastian, Feldt, Markus, Fukagawa, Misato, Goto, Miwa, Grady, Carol A., Guyon, Olivier, Hayano, Yutaka, Hayashi, Masahiko, Hayashi, Saeko S., Hebb, Leslie, Helminiak, Krzysztof G., Henning, Thomas, Hodapp, Klaus W., Ishii, Miki, Iye, Masanori, Janson, Markus, Kandori, Ryo, Knapp, Gillian R., Kuzuhara, Masayuki, Kwon, Jungmi, Matsuo, Taro, Mayama, Satoshi, Miyama, Shoken, Momose, Munetake, Morino, Jun-Ichi, Moro-Martin, Amaya, Nakagawa, Takao, Nishimura, Tetsuo, Oh, Daehyeon, Pyo, Tae-Soo, Schlieder, Joshua, Serabyn, Eugene, Sitko, Michael L., Suenaga, Takuya, Suto, Hiroshi, Suzuki, Ryuji, Takahashi, Yasuhiro H., Takami, Michihiro, Takato, Naruhisa, Terada, Hiroshi, Thalmann, Christian, Tomono, Daigo, Turner, Edwin L., Watanabe, Makoto, Yamada, Toru, Takami, Hideki, Usuda, Tomonori, Tamura, Motohide   +61 more
openaire   +2 more sources

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Fundamental parameters of subgiant stars in detached eclipsing binary systems [PDF]

, 2019
Detailed studies of stars in long-period, detached eclipsing binary systems remain one of the best ways to test stellar evolutionary models. With so many detections of planets outside of the solar system, research has turned to the characterisation of ...
Evans, Jessica Ann
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source