Results 151 to 160 of about 18,777 (215)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

A tidal disruption event from an intermediate-mass black hole revealed by comprehensive multi-wavelength observations. [PDF]

Nat Commun
Wang J, Huang M, Xue Y, Jiang N, Huang S, Wang Y, Zhu J, Zhu S, Dai L, Jin C, Luo B, Shu X, Sun M, Wang T, Zou F.   +14 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Uterine Contractility Changes in Adenomyosis: Evidence from a Systematic Review and Meta-Analysis. [PDF]

Biomedicines
Vidal A, Tepasse P, Vinayahalingam V, Cottagnoud S, Gulz M, Karrer T, Yilmaz G, Pape J, von Wolff M.   +8 more
europepmc   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Thoracic endovascular <i>vs</i> open surgical repair in descending thoracic aortic aneurysms: A systematic review and meta-analysis. [PDF]

World J Cardiol
Khawar M, Ali U, Rasheed MA, Rasheed AB, Shah SA, Zain S, Saifullah M, Mubarika M, Hadeed Khawar MM, Iqbal T, Ghuman SI, Rana I, Pathak P.   +12 more
europepmc   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Early Postoperative Endothelial Cell Density Predicts Graft Survival After Keratoplasty: A Systematic Review and Meta-Analysis. [PDF]

Cureus
Bonajmah H, Aljassar F.
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Ventricular Arrhythmia as a Presenting Feature in a Patient With Tubercular Myocarditis and Axillary Lymphadenopathy. [PDF]

JACC Case Rep
Nissar K, Abhinav AB, Vaideeswar P, Lanjewar C.   +3 more
europepmc   +1 more source