Results 111 to 120 of about 1,865,175 (347)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
ENTREPRENEURIAL SELLING: CHALLENGES OF AN ENTREPRENEUR WHO WANTED TO SAVE LIVES
Administração: Ensino e PesquisaThis case portrays the real challenges faced by Dr. Paulino Souza Neto, a vascular surgeon, radiologist, and inventor of technologies in the healthcare sector aimed at patient safety.
Renato Fernandes
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Development of statistical framework to evaluate the features of innovative start-ups in Ukraine
Статистика України, 2016 Governments of the leading countries, recognized that start-ups (from the English "start-up" - start) are the engines of innovative development of economy and making efforts, on the one hand, to create these basic conditions; on the other - to implement ...
O. B. Salikhova, O. O. Kurchenko
doaj
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Developing an Entrepreneurial Ecosystem Framework for Student-Led Start-Ups in Higher Education
Education SciencesHigher education institutions (HEIs) are increasingly seen as central actors in entrepreneurial ecosystems, yet their support mechanisms do not always align with the needs of student entrepreneurs.
Artūras Jurgelevičius +3 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Experimental investigation of hydrogen production performance of PEM electrolyze
Scientific ReportsAs global awareness of environmental protection increases, hydrogen is seen as a promising solution due to its high energy density and zero-emission combustion. The PEM electrolyze combined with renewable energy power generation is an effective method to
Chen Aijun +4 more
doaj +1 more source