Results 121 to 130 of about 7,517,121 (308)
The Environment at Play: Confronting Nature in The Elder Scrolls V: Skyrim and the “Frostfall” Mod
, 2019 In this paper, I argue that the natural environment in the base game of The Elder Scrolls V: Skyrim is devoid of agency and power in the face of the player’s colonialist endeavours to explore, conquer and master that environment.
Jansen, Dennis
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Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2007 Catalog of publications, videotapes, and services designed to provide resources for Head Start grantees and delegates to use in the planning, management, and operations of their programs.Includes indexes.Shipping list no.: 2007-0321-P.Cover title.Catalog
United States. Administration for Children and Families. +1 more
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Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Review: A Play of Bodies: How We Perceive Videogames
, 2021 Review: A Play of Bodies: How We Perceive Videogames, by Brendan Keogh. MIT Press. 2018.
Timss, Braden
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Development of statistical framework to evaluate the features of innovative start-ups in Ukraine
Статистика України, 2016 Governments of the leading countries, recognized that start-ups (from the English "start-up" - start) are the engines of innovative development of economy and making efforts, on the one hand, to create these basic conditions; on the other - to implement ...
O. B. Salikhova, O. O. Kurchenko
doaj
Stage-Specific Drivers of Startup Ambidexterity
Foresight and STI GovernanceThis paper considers the impact of ambidexterity, consisting of the relationship between exploration and exploitation, on the development of start-ups. The main goal of the study is to determine the importance of ambidexterity’s critical success factors
Pawel Mielcarek, Klaudiusz Kalisty
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source