Results 121 to 130 of about 1,473,436 (259)

The therapeutic opportunities and pitfalls of using iron ion chelators to treat neurodegenerative diseases

FEBS Letters, EarlyView.
Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley   +1 more source

Accelerating start-up cycles in investigator-initiated multicenter clinical trials. [PDF]

J Clin Transl Sci
Hillery S, Majkowski R, Wang Y, Barney B, Eyzaguirre L, Mould A, McBee N, Woo E, Holthouse E, Wiley K, Waddy SP, Ford D, Hanley DF, Lane K.   +13 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Enhancing start-up and torque in Darrieus VAWTs through a novel plain gurney flap design. [PDF]

Sci Rep
Eltayeb W, Somlal J, SirElkhatim M, Yedukondalu G, Srinath A.   +4 more
europepmc   +1 more source

Rapid Start-Up Characteristics of Anammox under Different Inoculation Conditions. [PDF]

Int J Environ Res Public Health, 2023
Tan Q, Xia S, Xu W, Jian Y.
europepmc   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Correction: Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts

Cell Death and Disease
Sara Baroni, S. Romero-Cordoba, I. Plantamura, M. Dugo, E. D’Ippolito, A. Cataldo, G. Cosentino, V. Angeloni, A. Rossini, M. G. Daidone, M. VIorio   +10 more
doaj   +1 more source

Correction to "A Practical Start-Up Guide for Synthetic Chemists to Implement Design of Experiments (DoE)". [PDF]

ACS Catal
Wall BJ, Koeritz MT, Stanley LM, VanVeller B.   +3 more
europepmc   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

"Voice is the New Blood": a discourse analysis of voice AI health-tech start-up websites. [PDF]

Front Digit Health
Blatter A, Gallois H, Evangelista E, Bensoussan Y, Bridge2AI-Voice Consortium, Bélisle-Pipon JC.   +5 more
europepmc   +1 more source