Results 111 to 120 of about 7,517,121 (308)
Food security challenges: Evidence from the southeast Europe countries
Biotechnologie, Agronomie, Société et EnvironnementDescription of the subject. In the past half-century, the world has become increasingly aware of the challenges and threats to food security. The challenges of maintaining food security have been further increased under the influence of crises (COVID-19,
Mina Kovljenić, Bojan Matkovski
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Start-up e nuove tecnologie, una reale opportunità di lavoro
, 2019 La relazione ha affrontato la disciplina dei rapporti di lavoro alle dipendenze delle start-up, con specifico riferimento alla deroga alla disciplina generale del contratto di lavoro a tempo determinato, agli spazi per la contrattazione collettiva nella ...
quadri giulio
core
Unpacking sustainability in start-ups: a systematic review and research agenda
Discover SustainabilityIn recent years, sustainability has gained much attention in the international environment, and introducing new products, processes, or practices for a sustainable future has become a key strategy for businesses.
Kijun Lee +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
, 2018 Developing technologies, digital media and mobile internet access have allowed members of the MSM community the opportunity to integrate their lives more fully into a world once dominated by exclusively straight places and communities - the change ...
Marshall, Conor
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
The Legal Nature of Video Games – Adapting Copyright Law to Multimedia
, 2015 In Copyright Law, video games are still a contentious matter. The multimedia nature of games brings up the question on how to define their legal nature. While there are several original underlying works in video games such as computer programs, artistic ...
Stein, Julian Simon
core
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source