Results 111 to 120 of about 10,515,708 (302)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Stage-Specific Drivers of Startup Ambidexterity
Foresight and STI GovernanceThis paper considers the impact of ambidexterity, consisting of the relationship between exploration and exploitation, on the development of start-ups. The main goal of the study is to determine the importance of ambidexterity’s critical success factors
Pawel Mielcarek, Klaudiusz Kalisty
doaj +1 more source
The Social Capital of Venture Capitalists and Its Impact on the Funding of Start-Up Firms [PDF]
How does the social capital of venture capitalists (VCs) affect the funding of start-ups? Extant entrepreneurship literature conceptualizes a substitute effect between the social and financial capital that new firms attain from their investors.
Sandner, P.G. +3 more
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Development of statistical framework to evaluate the features of innovative start-ups in Ukraine
Статистика України, 2016 Governments of the leading countries, recognized that start-ups (from the English "start-up" - start) are the engines of innovative development of economy and making efforts, on the one hand, to create these basic conditions; on the other - to implement ...
O. B. Salikhova, O. O. Kurchenko
doaj
Entrepreneurship and Regional Economic Growth: Towards A General Theory of Start-Ups [PDF]
Start-ups of new firms are important for economic growth. However, start-up rates differ significantly between countries and within regions of the same country.
Gries, Thomas, Naude, Wim
core
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
ENTREPRENEURIAL SELLING: CHALLENGES OF AN ENTREPRENEUR WHO WANTED TO SAVE LIVES
Administração: Ensino e PesquisaThis case portrays the real challenges faced by Dr. Paulino Souza Neto, a vascular surgeon, radiologist, and inventor of technologies in the healthcare sector aimed at patient safety.
Renato Fernandes
doaj +1 more source
Innovation and Start-up Creation
, 2006 Il testo tratta il tema dell'innovazione nella creazione di start-up ad alta ...
PERRINI, FRANCESCO
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source