Results 141 to 150 of about 1,473,436 (259)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

A Practical Start-Up Guide for Synthetic Chemists to Implement Design of Experiments (DoE). [PDF]

ACS Catal
Wall BJ, Koeritz MT, Stanley LM, VanVeller B.   +3 more
europepmc   +1 more source

Induction Motor Stator Winding Inter-Tern Short Circuit Fault Detection Based on Start-Up Current Envelope Energy. [PDF]

Sensors (Basel), 2023
Chen L, Shen J, Xu G, Chi C, Feng Q, Zhou Y, Deng Y, Wen H.   +7 more
europepmc   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Formation Mechanism and Model of the Initial Slag Layer on the Wall during the First-Time Start-Up Slagging Process in an Entrained Flow Gasifier. [PDF]

ACS Omega
Chen H, Zhang B, Lyu Z, Jin J, Wang Q, Liu H.   +5 more
europepmc   +1 more source

Using gamification to enhance clinical trial start-up activities. [PDF]

J Clin Transl Sci, 2022
Lane K, Majkowski R, Gruber J, Amirault D, Hillery S, Wieber C, Thompson DD, Huvane J, Bridges J, Ryu EP, Eyzaguirre LM, Gildea M, Thompson RE, Ford DE, Hanley D.   +14 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Swiss Life Sciences Start-ups – A 'tour d'horizon'

CHIMIA, 2014
Peter Burckhardt
doaj  

Inoculation Improves Microbial Manganese Removal during the Start-Up of Rapid Sand Filters. [PDF]

ACS ES T Water
Haukelidsaeter S, Boersma AS, Behrends T, Lenstra WK, van Helmond NAGM, Piso L, Schoonenberg F, van der Wielen PWJJ, van Kessel MAHJ, Lücker S, Slomp CP.   +10 more
europepmc   +1 more source

Employees' Entrepreneurial Dreams and Turnover Intention to Start-Up: The Moderating Role of Job Embeddedness. [PDF]

Int J Environ Res Public Health, 2022
Li M, Li J, Chen X.
europepmc   +1 more source