Results 81 to 90 of about 9,397,444 (297)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Power Control of a Nonpitchable PMSG-Based Marine Current Turbine at Overrated Current Speed With Flux-Weakening Strategy [PDF]

, 2014
This paper deals with power control strategies for a fixed-pitch direct drive marine current turbine (MCT) when the marine current velocity exceeds the rated value corresponding to the MCT nominal power.
SCUILLER, Franck, CHARPENTIER, Jean-Frederic, Zhou, Zibhin, BENBOUZID, Mohamed, ZHOU, Zhibin, TANG, Tianhao, Charpentier, Jean Fréderic   +6 more
core   +1 more source

Analisis perbandingan arus starting motor induksi 3 fasa

Jurnal Eltek
Motor induksi tiga fasa merupakan motor yang mengubah energi listrik menjadi energi mekanik dan banyak digunakan pada industri kecil maupun besar sebagai penggerak.
Linda Sartika, Abdul Muis Prasetia, Muhammad Allriz Akbar   +2 more
doaj   +1 more source

Research on soft start mode of grading discrete frequency conversion for mine asynchronous motor

Gong-kuang zidonghua, 2016
In view of problem that traditional soft start mode of mine-used asynchronous motor has big starting current, small starting torque, and cannot achieve overload or full load start, voltage regulation circuit and protection circuit were improved based on ...
WANG Dongfeng, ZHANG Kairu, WANG Yi, WANG Yongli   +3 more
doaj   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A Vectorial Approach for Generation of Optimal Current References for Multiphase Permanent-Magnet Synchronous Machines in Real Time [PDF]

, 2011
This paper deals with the generation of optimal current references for multiphase permanent-magnet (PM) synchronous machines in normal or fault mode (open-circuited phases).
KESTELYN, Xavier, SEMAIL, Eric, Eric Semail, Xavier Kestelyn   +3 more
core   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Research of frequency division starting method based on six-pulse-wave AC/AC frequency converter

Gong-kuang zidonghua, 2013
Based on analysis of six-pulse-wave AC/AC frequency converter and according to principle of dual-slope voltage soft starting method, a frequency division starting method based on six-pulse-wave AC/AC frequency converter was put forward.
LI Gao-ju, DU Qing-nan, GUO Hong-liang, LIANG Jing   +3 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source