Results 71 to 80 of about 4,863,810 (270)
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Molecular insights into pathogenic mechanisms in startle disease [PDF]
, 2012 This study describes an in-depth investigation into the pathogenic mechanisms of inherited mutations that lead to disorders of inhibitory glycinergic transmission, primarily the rare human disorder known as startle disease/hyperekplexia.
James, Victoria
core +1 more source
Battery‐Inspired Electrochemical Synapses for Neuromorphic Applications
Advanced Science, EarlyView.Battery‐ion‐inspired synaptic devices integrate diverse electrolyte systems (solid, ion‐gel, liquid) with transition metal oxides, two‐dimensional materials, and organic channels to regulate ion‐electron coupling. By tailoring ion transport and host interactions, these platforms enable controllable plasticity and energy‐efficient implementations for ...
Won Woo Lee +6 more
wiley +1 more source
Disease Models & Mechanisms, 2014 Canavan disease is a leukodystrophy caused by mutations in the ASPA gene. This gene encodes the enzyme that converts N-acetylaspartate into acetate and aspartic acid.
Marina R. Carpinelli +6 more
doaj +1 more source
Startle-like behaviors of Hb+ N. coriiceps and Hb- C. aceratus as a function of temperature.
, 2021 (A) Time plots of angular velocity (Va) during startle-like maneuvers at respective temperatures in a single specimen of N. coriiceps and C. aceratus. Rainbow color code denotes the continuum of angular velocities from low (violet) to high (red) during ...
Iraida E. Andreeva (11751822) +3 more
core +1 more source
VlPAG/DRN Microglia Drive Neuropathic Pain‐Induced Depression via a Defined Neuroimmune Axis
Advanced Science, EarlyView.Peripheral nerve injury (SNI) induces neuropathic pain, activates midbrain microglia, and triggers an NLRP3–IL‐1β–dependent inflammatory cascade. IL‐1β signals through IL‐1R1 on vlPAG/DRN VGLUT2+ neurons (vlPAG/DRNGlu), inducing hyperexcitability and driving the vlPAG/DRNGlu→BNSTGABA circuit to produce the affective component of neuropathic pain ...
Jing Yang +7 more
wiley +1 more source
Advanced Science, EarlyView.An AI‐enabled digital twin framework integrates wearable EMG sensing with hierarchical multi‐domain fusion to classify chronic ankle instability, distinguish clinically relevant subtypes, and generate continuous motor function scores. Clinically interpretable functional stratification and SHAP‐based biomarker analysis provide transparent decision ...
Tianle Jie +12 more
wiley +1 more source
Sporadic hyperekplexia due to self-limiting brainstem encephalopathy
Neuropsychiatric Disease and Treatment, 2017 Dilek Yilmaz,1 Bülent Cengiz2 1Department of Neurology, Konya Numune State Hospital, Konya, 2Department of Neurology, Gazi University Faculty of Medicine, Ankara, Turkey Abstract: Hyperekplexia is a rare movement disorder characterized by ...
Yilmaz D, Cengiz B
doaj
Advanced Science, EarlyView.CDegSR, a new tool for imaging RNA at single molecule level in living cells was developed by researchers. Background noise was eliminated by protein engineering and making it degrade when not bound to its target. This allowed individual RNA molecules to be clearly imaged and tracked.
Shipeng Shao, Hongchen Zhang
wiley +1 more source
A case of V180I genetic Creutzfeldt-Jakob disease presenting with conspicuous facial mimicry
Prion, 2019 Although there have been no reports of facial mimicry in patients with Creutzfeldt-Jakob disease (CJD), we encountered a patient with genetic CJD with prion protein gene codon 180 mutation (V180I gCJD) who apparently showed this interesting clinical ...
Yasushi Iwasaki +3 more
doaj +1 more source