Results 51 to 60 of about 13,168 (270)

Loss of Cochlear Ribbon Synapse Is a Critical Contributor to Chronic Salicylate Sodium Treatment-Induced Tinnitus without Change Hearing Threshold

Neural Plasticity, 2020
Tinnitus is a common auditory disease worldwide; it is estimated that more than 10% of all individuals experience this hearing disorder during their lifetime. Tinnitus is sometimes accompanied by hearing loss.
Wei Zhang, Zhe Peng, ShuKui Yu, Qing-Ling Song, Teng-Fei Qu, Lu He, Ke Liu, Shu-Sheng Gong   +7 more
doaj   +1 more source

Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis–Associated Interstitial Lung Disease Risk

Arthritis Care &Research, EarlyView.
Objective The purpose was to evaluate a biomarker score consisting of MUC5B rs35705950 promoter variant, plasma matrix metalloproteinase‐7 (MMP‐7), and serum anti–malondialdehyde‐acetaldehyde (anti‐MAA) antibody for rheumatoid arthritis (RA)–associated interstitial lung disease (ILD) risk stratification.
Kelsey Coziahr, Austin M. Wheeler, Brent A. Luedders, Michael Duryee, Halie Frideres, Katherine D. Wysham, Grant W. Cannon, Gary Kunkel, Dana P. Ascherman, Paul A. Monach, Gail S. Kerr, Andreas M. Reimold, Scott M. Matson, Joshua F. Baker, Geoffrey M. Thiele, Ted R. Mikuls, Bryant R. England   +16 more
wiley   +1 more source

Novel use of FDA-approved drugs identified by cluster analysis of behavioral profiles

Scientific Reports, 2022
Repurposing FDA-approved drugs is an efficient and cost-effective approach in the development of therapeutics for a broad range of diseases. However, prediction of function can be challenging, especially in the brain. We screened a small-molecule library
Sara Tucker Edmister, Thaís Del Rosario Hernández, Rahma Ibrahim, Cameron A. Brown, Sayali V. Gore, Rohit Kakodkar, Jill A. Kreiling, Robbert Creton   +7 more
doaj   +1 more source

Bioinspired Adaptive Sensors: A Review on Current Developments in Theory and Application

Advanced Materials, EarlyView.
This review comprehensively summarizes the recent progress in the design and fabrication of sensory‐adaptation‐inspired devices and highlights their valuable applications in electronic skin, wearable electronics, and machine vision. The existing challenges and future directions are addressed in aspects such as device performance optimization ...
Guodong Gong, You Zhou, Qingxiu Li, Wenyu Zhao, Sunyingyue Geng, Hangfei Li, Yan‐Bing Leng, Shirui Zhu, Guanglong Ding, Yongbiao Zhai, Ziyu Lv, Ye Zhou, Su‐Ting Han   +12 more
wiley   +1 more source

Conceptualising quality early childhood education: Learning from young children in Brazil and South Africa through creative and play‐based methods

British Educational Research Journal, EarlyView., 2023
Abstract Early childhood has increasingly been acknowledged as a vital time for all children. Inclusive and quality education is part of the United Nations Sustainable Development Goals, with the further specification that all children have access to quality pre‐primary education.
Laura H. V. Wright, Irene Rizzini, Malibongwe Gwele, Lynn McNair, Cristina Laclette Porto, Marsha Orgill, E. Kay M. Tisdall, Malcolm Bush, Linda Biersteker   +8 more
wiley   +1 more source

Stretchable and Strain‐Tolerant Gold‐Coated Fibrous Biosensor for Superoxide Anion Monitoring

Advanced Materials Technologies, EarlyView.
A breathable, stretchable gold nanomesh–TPU fiber platform is developed via controlled electroless deposition, enabling uniform through‐thickness conductivity while preserving porosity. Functionalized with superoxide dismutase, the system achieves selective, real‐time electrochemical detection of superoxide with high sensitivity, mechanical durability,
Jafar M. Batayneh, Ahyeon Koh
wiley   +1 more source

Strong‐Magnetic Flexible Composites for Magnetically Responsive Soft Robots

Advanced Robotics Research, EarlyView.
This perspective provides an overview of the performance mechanisms, preparation methods, and applications of strong magnetic flexible composite materials in soft actuators (such as gripping, movement, and sensing), and further explores current opportunities and challenges.
Wenwen Li, Shuai Liu, Xinyi Wang, Xinglong Gong, Shouhu Xuan   +4 more
wiley   +1 more source

Molecular insights into pathogenic mechanisms in startle disease [PDF]

, 2012
This study describes an in-depth investigation into the pathogenic mechanisms of inherited mutations that lead to disorders of inhibitory glycinergic transmission, primarily the rare human disorder known as startle disease/hyperekplexia.
James, Victoria
core  

Hard‐Magnetic Soft Millirobots in Underactuated Systems

Advanced Robotics Research, EarlyView.
This review provides a comprehensive overview of hard‐magnetic soft millirobots in underactuated systems. It examines key advances in structural design, physics‐informed modeling, and control strategies, while highlighting the interplay among these domains.
Qiong Wang, Zixuan Zhang, Bingyan Li, Junkai Wang, Hongcheng Gu   +4 more
wiley   +1 more source

In depth behavioral phenotyping unravels complex motor disturbances in Cstb−/− mouse, a model for progressive myoclonus epilepsy type 1

Frontiers in Behavioral Neuroscience, 2023
Progressive myoclonus epilepsy type 1 (EPM1) is an autosomal recessively inherited childhood–adolescence onset neurodegenerative disease caused by mutations in the cystatin B (CSTB gene).
Eveliina Pollari, Saara Tegelberg, Harry Björklund, Reetta Kälviäinen, Reetta Kälviäinen, Anna-Elina Lehesjoki, Antti Haapalinna   +6 more
doaj   +1 more source