Results 31 to 40 of about 13,168 (270)

Transcriptional Profile Changes after Noise-Induced Tinnitus in Rats

Brain Sciences, 2023
Tinnitus is an unpleasant symptom characterized by detective hearing without the actual sound input. Despite numerous studies elucidating a variety of pathomechanisms inducing tinnitus, the pathophysiology of tinnitus is not fully understood.
Peng Liu, Xinmiao Xue, Chi Zhang, Hanwen Zhou, Zhiwei Ding, Li Wang, Yuke Jiang, Weidong Shen, Shiming Yang, Fangyuan Wang   +9 more
doaj   +1 more source

Transcranial Direct Current Stimulation Over Motor Areas Improves Reaction Time in Parkinson's Disease

Frontiers in Neurology, 2022
BackgroundTranscranial direct current stimulation (tDCS) has been shown to modulate cortical motor excitability and improve bradykinesia symptoms in Parkinson's disease.
Christin M. Sadler, Aline Tiemi Kami, Julie Nantel, Jonathan Lommen, Anthony N. Carlsen   +4 more
doaj   +1 more source

Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency

Molecular Brain, 2023
Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha (α1–4) and β subunits. The GlyR subunits play major roles in the mammalian central nervous system, ranging from regulating simple sensory information to modulating higher-order
Mohamed Darwish, Satoko Hattori, Hirofumi Nishizono, Tsuyoshi Miyakawa, Nozomu Yachie, Keizo Takao   +5 more
doaj   +1 more source

Reduced Acoustic Startle Response and Prepulse Inhibition in the Tg4-42 Model of Alzheimer’s Disease

Journal of Alzheimer's Disease Reports, 2019
Sensorimotor deficits have been described in several neuropsychiatric disorders including Alzheimer’s disease. The aim of the present study was to evaluate possible sensorimotor gating deficits in the Tg4-42 mouse model of Alzheimer’s disease using the ...
Marius E. Sichler, Maximilian J. Löw, Eva M. Schleicher, Thomas A. Bayer, Yvonne Bouter   +4 more
doaj   +1 more source

Hyperekplexia; Response to Clonazepam

Pediatric Neurology Briefs, 1992
Sixteen patients, including 1 neonate, in a large 5 generation family with hyperekplexia (startle disease or congenital stiff-man syndrome) were treated with clonazepam at the University of Texas Health Science Center, San Antonio, TX.
J Gordon Millichap
doaj   +1 more source

A novel compound mutation in GLRA1 cause hyperekplexia in a Chinese boy- a case report and review of the literature

BMC Medical Genetics, 2017
Background The pathogenesis of hereditary hyperekplexia is thought to involve abnormalities in the glycinergic neurotransmission system, the most of mutations reported in GLRA1.
Zhiliang Yang, Guilian Sun, Fang Yao, Dongying Tao, Binlu Zhu   +4 more
doaj   +1 more source

Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice

eLife, 2022
Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice.
Knut Sindre Åbjørsbråten, Gry HE Syverstad Skaaraas, Céline Cunen, Daniel M Bjørnstad, Kristin M Gullestad Binder, Laura Bojarskaite, Vidar Jensen, Lars NG Nilsson, Shreyas B Rao, Wannan Tang, Gudmund Horn Hermansen, Erlend A Nagelhus, Ole Petter Ottersen, Reidun Torp, Rune Enger   +14 more
doaj   +1 more source

4-Chloropropofol enhances chloride currents in human hyperekplexic and artificial mutated glycine receptors

BMC Neurology, 2012
Background The mammalian neurological disorder hereditary hyperekplexia can be attributed to various mutations of strychnine sensitive glycine receptors.
de la Roche Jeanne, Leuwer Martin, Krampfl Klaus, Haeseler Gertrud, Dengler Reinhard, Buchholz Vanessa, Ahrens Jörg   +6 more
doaj   +1 more source

Startle Habituation and Midfrontal Theta Activity in Parkinson Disease [PDF]

Journal of Cognitive Neuroscience, 2016
The ability to adapt to aversive stimuli is critical for mental health. Here, we investigate the relationship between habituation to startling stimuli and startle-related activity in medial frontal cortex as measured by EEG in both healthy control participants and patients with Parkinson disease (PD). We report three findings.
Kuan-Hua Chen, Katrina L. Okerstrom, Jonathan R. Kingyon, Steven W. Anderson, James F. Cavanagh, Nandakumar S. Narayanan   +5 more
openaire   +2 more sources

Mutations in the GlyT2 gene (SLC6A5) are a second major cause of startle disease [PDF]

, 2012
Hereditary hyperekplexia or startle disease is characterized by an exaggerated startle response, evoked by tactile or auditory stimuli, leading to hypertonia and apnea episodes.
Carta, E., Del Toro, M., Scalais, E., Topf, M., Harvey, R. J., Rees, M. I., Masri, A., Rivera, S., Supplisson, S., Manzur, A. Y., Stuart, C. A., Graham, G. E., Harvey, K., James, V. M., Remy, N., Cagdas, S., Cameron, D., Pearce, B. R., Tijssen, M. A. J., Thomas, Rhys Huw, Drew, C. J. G., Gill, J. L., Wise, G., Zuberi, S. M., Sinclair, K., Robinson, A., Chung, S.-K., Cowan, F. M., Vanbellinghen, J.-F., Shiang, R.   +29 more
core   +2 more sources