Results 31 to 40 of about 4,863,810 (270)
Fingolimod mitigates synaptic deficits and psychosis‐like behavior in APP/PSEN1 mice
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2022 Introduction Current treatments for psychosis in Alzheimer's disease (AD), a syndrome characterized by more rapid deterioration and reduced synaptic protein abundance relative to non‐psychotic AD, are inadequate.
Josh M. Krivinko +4 more
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Transcriptional Profile Changes after Noise-Induced Tinnitus in Rats
Brain Sciences, 2023 Tinnitus is an unpleasant symptom characterized by detective hearing without the actual sound input. Despite numerous studies elucidating a variety of pathomechanisms inducing tinnitus, the pathophysiology of tinnitus is not fully understood.
Peng Liu +9 more
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Comprehensive behavioral analyses of mice with a glycine receptor alpha 4 deficiency
Molecular Brain, 2023 Glycine receptors (GlyRs) are ligand-gated chloride channels comprising alpha (α1–4) and β subunits. The GlyR subunits play major roles in the mammalian central nervous system, ranging from regulating simple sensory information to modulating higher-order
Mohamed Darwish +5 more
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Startle disease—hyperekplexia (two sibling cases)
Seizure, 1996 Two sisters aged 12 and 13 applied to our hospital with complaints of jerking tonic contraction triggered by sudden noise. Diffuse bilaterally polyspike-wave discharges appeared on waking electroencephalography and during that time a startle-induced tonic contraction was seen.
Altunbaşak Ş., Baytok V.
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Reduced Acoustic Startle Response and Prepulse Inhibition in the Tg4-42 Model of Alzheimer’s Disease
Journal of Alzheimer's Disease Reports, 2019 Sensorimotor deficits have been described in several neuropsychiatric disorders including Alzheimer’s disease. The aim of the present study was to evaluate possible sensorimotor gating deficits in the Tg4-42 mouse model of Alzheimer’s disease using the ...
Marius E. Sichler +4 more
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Hyperekplexia; Response to Clonazepam
Pediatric Neurology Briefs, 1992 Sixteen patients, including 1 neonate, in a large 5 generation family with hyperekplexia (startle disease or congenital stiff-man syndrome) were treated with clonazepam at the University of Texas Health Science Center, San Antonio, TX.
J Gordon Millichap
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BMC Medical Genetics, 2017 Background The pathogenesis of hereditary hyperekplexia is thought to involve abnormalities in the glycinergic neurotransmission system, the most of mutations reported in GLRA1.
Zhiliang Yang +4 more
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Impaired astrocytic Ca2+ signaling in awake-behaving Alzheimer’s disease transgenic mice
eLife, 2022 Increased astrocytic Ca2+ signaling has been shown in Alzheimer’s disease mouse models, but to date no reports have characterized behaviorally induced astrocytic Ca2+ signaling in such mice.
Knut Sindre Åbjørsbråten +14 more
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BMC Neurology, 2012 Background The mammalian neurological disorder hereditary hyperekplexia can be attributed to various mutations of strychnine sensitive glycine receptors.
de la Roche Jeanne +6 more
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Startle Habituation and Midfrontal Theta Activity in Parkinson Disease [PDF]
Journal of Cognitive Neuroscience, 2016 The ability to adapt to aversive stimuli is critical for mental health. Here, we investigate the relationship between habituation to startling stimuli and startle-related activity in medial frontal cortex as measured by EEG in both healthy control participants and patients with Parkinson disease (PD). We report three findings.
Kuan-Hua Chen +5 more
openaire +3 more sources