Results 181 to 190 of about 490,905 (276)

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

MTR4 methylation-dependent degradation activates mTORC1 signaling to promote glioma cell survival under methionine starvation. [PDF]

Amino Acids
Wang L, Lou Q, Chang J, Xu Z, Yang F, Tu Q, Zhang J, Xu W, Tong M.   +8 more
europepmc   +1 more source

Versatile DNA Hydrogel‐Mediated Delivery of Ginsenoside‐Encapsulated Small Extracellular Vesicles to Boost Diabetic Wound Repair

Advanced Science, EarlyView.
This study presents a DNA hydrogel‐mediated delivery system, in which ginsenoside (GS) molecules are incorporated into small extracellular vesicles (sEV) secreted by mesenchymal stem cells (MSCs) and the formed complexes are then anchored in DNA hydrogels via aptamer‐CD63 affinity as “GS/sEV@DNAgels”, to improve diabetic wound repair.
Jianming Xing, Shuangyang Li, Yuning Wang, Xushuang Jia, Ruiting Lin, Xintong Liu, Dongxu Wang, Ning Cui, Peng Ji, Jiaqi Chen, Shengnian Wang, Guangzhe Li, Ye Teng, Da Liu, Ye Jin   +14 more
wiley   +1 more source

Chemical Proteomics Identifies Ketogenesis‐Mediated Cysteine Modifications Regulating Redox Function

Angewandte Chemie, EarlyView.
Herein, we report ketone body induce cysteine modifications beyond lysine acylation, as revealed by integrating chemical proteomics with open‐search methods. Among the modifications, cysteine crotonation (Ccr) was chemically validated by endogenous peptide‐based co‐elution assays.
Yuan‐Fei Zhou, Ling Zhang, Zhuoyi L. Niu, Xin Wang, Alejandro Storper, Ryan Hunt, Yingming Zhao, Nima Sharifi, Zhipeng A. Wang   +8 more
wiley   +2 more sources

TFEB coordinates autophagosome biogenesis and ribophagy during starvation via SQSTM1. [PDF]

Sci Adv
Iavazzo M, Cinque L, Levantovsky S, Morrone C, Monfregola J, Raimondi A, Polishchuk E, De Cegli R, Carrella D, Nusco E, Ferrante L, Sacco F, Frankel LB, Behrends C, Settembre C.   +14 more
europepmc   +1 more source

Quantification of Single‐Cell Cysteine Using an Electrochemical Nanosensor for Predicting Tumor Disulfidptosis Susceptibility

Advanced Science, EarlyView.
Cysteine attracts interest due to its unique electrochemical activity and emerging relationship with disulfidptosis. This study develops a new electrochemical nanosensor, which represents the first of its kind capable of detecting intracellular cysteine for various types of tumor cells and primary tumor cells in mice to evaluate disulfidptosis ...
Congcong Zhang, Xiangdi Zhang, Shushen Li, Yuyang Li, Bei Yuan, Mingshuang Zheng, Shuo Zhang, Fangping Yuan, Min Jia, Lixia Lu, Jun Zhou, Zhenguo Zhang, Xin Du   +12 more
wiley   +1 more source

Autophagy cargo profiles in skeletal muscle during starvation and exercise. [PDF]

Autophagy Rep
Farhan M, Lyu S, Nguyen TP, Zhang D, Liang H, Zhou Y, An YA, Wang J, Yang H, Du G, Liu Y.   +10 more
europepmc   +1 more source

Electric‐Field‐Driven Bilayer Interphase from Oxygenated Nanodiamond‐Carbon Nanoparticles for Dendrite‐Free Lithium Metal Batteries

Advanced Energy Materials, EarlyView.
Electric‐field‐driven carbon migration within an oxygen‐functionalized nanodiamond/carbon composite induces the formation of a vertically graded interphase that homogenizes Li‐ion flux and suppresses dendritic nucleation. This hierarchically organized structure stabilizes the electrode–electrolyte interface and delivers durable, dendrite‐free operation
Jaeseong Kim, Incheol Heo, Dong‐Kyung Kim, Min Seok Kang, Ji Hee Kwon, Byeong‐Seon An, Keir C. Neuman, Byung‐Hyun Kim, Hak‐Sung Jung, Won Cheol Yoo   +9 more
wiley   +1 more source

A Generalizable Transformer Framework for Gene Regulatory Network Inference from Single‐Cell Transcriptomes

Advanced Intelligent Systems, EarlyView.
FTGRN introduces an LLM‐enhanced framework for gene regulatory network inference through a two‐stage workflow. It combines a Transformer‐based model, pretrained on GPT‐4 derived gene embeddings and regulatory knowledge, with a fine‐tuning stage utilizing single‐cell RNA‐seq data.
Guangzheng Weng, Hyobin Kim, Patrick Martin, Junil Kim, Tae‐Hyung Kim, Gi‐Hoon Nam, Dongha Kim, Kyoung Jae Won   +7 more
wiley   +1 more source

Electrophysiological monitoring of nutrient stress in <i>Oscillatoria</i> sp. cohorts: Toward an early-warning tool for harmful algal blooms. [PDF]

MRS Adv
Duci D, Amaral R, Silva DMS, Cotta FC, Bacellar FL, Bryant L, Perkins RG, Rocha PRF.   +7 more
europepmc   +1 more source