Results 141 to 150 of about 1,741,412 (341)
Biocatalytic Nanoregulators Restore Joint Redox‐Immune Homeostasis in Rheumatoid Arthritis
Advanced Science, EarlyView.Mesenchymal stem cell‐derived extracellular vesicles (EVs) coat ruthenium‐loaded metal‐organic frameworks (Ru@ZrMOF), creating a targeted therapeutic (Ru@ZrMOF/EVs). This platform scavenges ROS, generates oxygen, and polarizes macrophages from M1 to M2, alleviating inflammation, inhibiting pannus, promoting cartilage repair, and downregulating HIF‐1α ...
Xingheng Wang +7 more
wiley +1 more source
Measurements of the rare decay K_{L} -> e^{+} e^{-} e^{+} e^{-}
, 2001 We observe 441 K_{L} -> e^{+} e^{-} e^{+} e^{-} candidate events with a background of 4.2 events and measure B(K_{L} -> e^{+} e^{-} e^{+} e^{-}) = (3.72 \pm 0.18(stat) \pm 0.23(syst)) \times 10^{-8} in the KTeV/E799II experiment at Fermilab.
A. Alavi-Harati +93 more
core +2 more sources
Advanced Science, EarlyView.Fibroblast activation protein alpha‐positive (FAPα+) macrophages, a distinct subset of multiple myeloma (MM)‐associated macrophages, drive immune evasion in MM through multi‐faceted mechanisms. FAPα physically interacts with vimentin (VIM) and triggers its phosphorylation at the S72 residue, which in turn induces PD‐L1 transcription. Additionally, FAPα
Huiyao Gu +15 more
wiley +1 more source
Bufalin Inhibits the PI3K/AKT Pathway by Targeting GTF3C4 to Impede Breast Cancer Progression
Advanced Science, EarlyView.Mechanisms of Bufalin‐Mediated Intervention in Breast Cancer. ABSTRACT Breast cancer incidence is rising globally, presenting challenges such as treatment side effects and drug resistance. Bufalin is a bufadienolides compound with potential anti‐cancer effects. This study shows that bufalin inhibits malignant proliferation of MDA‐MB‐231 and MCF‐7 cells
Siyu Guo +15 more
wiley +1 more source
Studia Universitatis Moldaviae: Stiinte ale Educatiei, 2017 Unul dintre conflictele motivaţionale întâlnite frecvent în mediul organizaţional este „conflictul familie-muncă”. Conflictul, în acest caz, derivă din nevoia de a integra în mod optim solicitările legate de rolul familial cu cele ale rolului profesional.
Carolina PLATON +9 more
doaj
Improved Measurement of the Form Factors in the Decay Lambda_c^+ --> Lambda e^+ nu_e
, 2005 Using the CLEO detector at the Cornell Electron Storage Ring, we have studied the distribution of kinematic variables in the decay Lambda_c^+ -> Lambda e^+ nu_e. By performing a four-dimensional maximum likelihood fit, we determine the form factor ratio,
A. Bornheim +134 more
core +1 more source
Advanced Science, EarlyView.Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan +11 more
wiley +1 more source
PEPTIDE BIOACTIVE ALGALE ŞI PERSPECTIVA DE UTILIZARE A LOR ÎN CALITATE DE AGENŢI TERAPEUTICI
Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2015 Dezvoltarea şi aplicarea tehnologiilor de inginerie enzimatică, folosind enzimele pentru hidroliza ficocianinei şi producerea peptidelor bioactive, deschide noi perspective de utilizare a lor în calitate de agenţi anticancer, antimicro-bieni ...
Valentina BULIMAGA +5 more
doaj
Advanced Science, EarlyView.IL‐15‐engineered stem cell–NK cell complexes, assembled via bioorthogonal chemistry, enable effective lung cancer immunotherapy. Abstract Natural killer (NK) cells represent a powerful immunotherapeutic strategy due to their intrinsic cytotoxicity and ability to target tumor cells independently of antigen presentation.
Qian Zhang +15 more
wiley +1 more source
Advanced Science, EarlyView.Wedelolactone (WED), a natural TLR2 agonist, promotes neutrophil differentiation and enhances bactericidal function, offering a potential therapeutic strategy for neutropenia. Using a multi‐omics approach, this study reveals that WED activates the TLR2/MEK/ERK pathway, upregulating key transcription factors (PU.1, CEBPβ) to drive neutrophil development.
Long Wang +16 more
wiley +1 more source