Results 121 to 130 of about 1,654,341 (292)
Advanced Science, EarlyView.The PBTN targets GRP78 and, upon X‐ray irradiation, generates ONOO− to induce immunogenic cell death, thereby activating CD8+ T cells and establishing a systemic antitumor immune response. ABSTRACT Nitric oxide (NO) treated radioresistant tumors by relieving hypoxia and blocking DNA repair, but its nonselective toxicity has precluded therapeutic use ...
Wanze Zhang +10 more
wiley +1 more source
Agricultural Science, 2020 The aim of the study has been to determine the optimum period and the efficiency of the use of the automated installation with low energy consumption for milk cooling using natural cold. The use of the natu-ral cooling installation in the
Anatolie DAICU +6 more
doaj
Advanced Science, EarlyView.ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei +11 more
wiley +1 more source
PROPRIETĂŢILE TERAPEUTICE ALE PRODUSELOR APICOLE
Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2018 Produsele apicole reprezintă o sursă bogată de calorii şi o excelentă sursă de substanţe nutritive, conţinând o bogată varietate de vitamine. De asemenea, asigură sau completează mecanisme care se desfăşoară în mod natural într-un organism.
Aurelia CRIVOI +5 more
doaj
Macrophage Extracellular Traps in Immunity and Cancer
Advanced Science, EarlyView.As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li +5 more
wiley +1 more source
, 2004 Preliminary results on the measurement of the top quark mass (mt) at the Tevatron Collider are presented. In the dilepton decay channel, the CDF Collaboration measures mt=175.0(+17.4)(-16.9)(stat.)+/-8.4(syst.) GeV/c2, using a sample of ~126 pb-1 of ...
Cerrito, L.
core +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
Studia Universitatis Moldaviae: Stiinte reale si ale naturii, 2017 În prezenta lucrare a fost realizată sinteza 1,1-dimetil-3-(3-metil-5-sulfanil-4H-1,2,4-triazol-4-il)tioureei (5) şi a 1,1-dimetil-3-[3-metil-5-(metilsulfanil)-4H-1,2,4-triazol-4-il]tioureei (6), ale căror structuri au fost stabilite cu ajutorul ...
Anna RUSNAC +4 more
doaj
Propulsion Study for Small Transport Aircraft Technology (STAT) [PDF]
Propulsion requirements were determined for 0.5 and 0.7 Mach aircraft. Sensitivity studies were conducted on both these aircraft to determine parametrically the influence of propulsion characteristics on aircraft size and direct operating cost (DOC ...
Earle, R. V. +5 more
core +1 more source
Advanced Science, EarlyView.Cer24:1 levels are reduced in neutrophilic asthma and inversely correlate with disease severity and airway neutrophilia. Restoring Cer24:1 suppresses pathogenic Th17 differentiation by engaging EP2 on CD4+ T cells, thereby dampening the JAK2–STAT3–RORγt axis and reducing IL‐17 production.
Huan Liu +11 more
wiley +1 more source