Results 1 to 10 of about 79,832 (300)

Transcription factor c-fos induces the development of premature ovarian insufficiency by regulating MALAT1/miR-22-3p/STAT1 network

Journal of Ovarian Research, 2023
Background The current study attempted to investigate the role of transcription factor c-fos in the development of premature ovarian insufficiency (POI) as well as the underlying mechanism involving the MALAT1/miR-22-3p/STAT1 ceRNA network.
Ting Qiu, Jie Zhou, Bing Ji, Liuyang Yuan, Tingsong Weng, Huishu Liu   +5 more
doaj   +3 more sources

The Signal Transducer and Activator of Transcription 1 (STAT1) Inhibits Mitochondrial Biogenesis in Liver and Fatty Acid Oxidation in Adipocytes. [PDF]

PLoS ONE, 2015
The transcription factor STAT1 plays a central role in orchestrating responses to various pathogens by activating the transcription of nuclear-encoded genes that mediate the antiviral, the antigrowth, and immune surveillance effects of interferons and ...
Jennifer D Sisler, Magdalena Morgan, Vidisha Raje, Rebecca C Grande, Marta Derecka, Jeremy Meier, Marc Cantwell, Karol Szczepanek, William J Korzun, Edward J Lesnefsky, Thurl E Harris, Colleen M Croniger, Andrew C Larner   +12 more
doaj   +5 more sources

The Inflammatory Transcription Factors NFκB, STAT1 and STAT3 Drive Age-Associated Transcriptional Changes in the Human Kidney.

PLoS Genetics, 2015
Human kidney function declines with age, accompanied by stereotyped changes in gene expression and histopathology, but the mechanisms underlying these changes are largely unknown.
Zach K O'Brown, Eric L Van Nostrand, John P Higgins, Stuart K Kim   +3 more
doaj   +3 more sources

N-terminal truncation of STAT1 transcription factor causes CD3- and CD20-negative non-Hodgkin lymphoma through upregulation of STAT3-mediated oncogenic functions [PDF]

Cell Communication and Signaling
The cytokine-driven transcription factor STAT1 (signal transducer and activator of transcription 1) executes anti-microbial and pro-apoptotic functions, and loss-of-function mutations are associated with increased susceptibility to various infections and
Sana Mumtaz Sheikh, Julia Staab, Martina Bleyer, Aleksandar Ivetic, Fred Lühder, Oliver Wirths, Thomas Meyer   +6 more
doaj   +2 more sources

CYP8B1 inhibits hepatocellular carcinoma progression by repressing PAK4 transcription through inhibition of nuclear translocation of u-STAT1 [PDF]

Cell Death and Disease
Primary and secondary bile acid (BA) levels are elevated in patients with hepatocellular carcinoma (HCC). BAs are important signaling molecules that regulate CYP8B1 expression by targeting nuclear and membrane receptors.
Le Xu, Lin Xiong, Jingping Yuan, Yukai Chen, Fangfang Chen, Siyu Wang, Ximing Xu   +6 more
doaj   +2 more sources

Identification of the E3 ligase TRIM21 as a crucial regulator of STAT1 in metabolic dysfunction—associated steatohepatitis [PDF]

Cell Communication and Signaling
background and aims Metabolic associated fatty liver disease (MAFLD) is closely associated with metabolic disorders, including central obesity, dyslipidaemia, hypertension, hyperglycaemia and persistent abnormalities of liver function tests.
Xun-Xun Chen, Hui-Ting Shi, Li-Li Xiao, Huan Li, Bin-Bin Du, Zhen Huang, Dian-Hong Zhang, Lei-Ming Wu, Li-Na Wu, Jie-Lei Zhang   +9 more
doaj   +2 more sources

Porcine Epidemic Diarrhea Virus Antagonizes Host IFN-λ-Mediated Responses by Tilting Transcription Factor STAT1 toward Acetylation over Phosphorylation To Block Its Activation

mBio, 2023
Porcine epidemic diarrhea virus (PEDV) is the main etiologic agent causing acute swine epidemic diarrhea, leading to severe economic losses to the pig industry.
Jidong Xu, Qin Gao, Weiwu Zhang, Jingyou Zheng, Rong Chen, Xiao Han, Junyong Mao, Ying Shan, Fushan Shi, Fang He, Weihuan Fang, Xiaoliang Li   +11 more
doaj   +1 more source

Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease. [PDF]

PLoS Genetics, 2006
The transcription factor signal transducer and activator of transcription-1 (STAT1) plays a key role in immunity against mycobacterial and viral infections.
Ariane Chapgier, Stéphanie Boisson-Dupuis, Emmanuelle Jouanguy, Guillaume Vogt, Jacqueline Feinberg, Ada Prochnicka-Chalufour, Armanda Casrouge, Kun Yang, Claire Soudais, Claire Fieschi, Orchidée Filipe Santos, Jacinta Bustamante, Capucine Picard, Ludovic de Beaucoudrey, Jean-François Emile, Peter D Arkwright, Robert D Schreiber, Claudia Rolinck-Werninghaus, Angela Rösen-Wolff, Klaus Magdorf, Joachim Roesler, Jean-Laurent Casanova   +21 more
doaj   +1 more source

The Dual Role of STAT1 in Ovarian Cancer: Insight Into Molecular Mechanisms and Application Potentials

Frontiers in Cell and Developmental Biology, 2021
The signal transducer and activator of transcription 1 (STAT1) is a transducer protein and acts as a transcription factor but its role in ovarian cancer (OC) is not completely understood. Practically, there are two-faced effects of STAT1 on tumorigenesis
Xin Li, Xin Li, Fanchen Wang, Fanchen Wang, Xiaolin Xu, Xiaolin Xu, Jinguo Zhang, Jinguo Zhang, Guoxiong Xu, Guoxiong Xu   +9 more
doaj   +1 more source

MiR-19a-3p Suppresses M1 Macrophage Polarization by Inhibiting STAT1/IRF1 Pathway

Frontiers in Pharmacology, 2021
Macrophages, an important type of immune cells, are generally polarized to classically activated macrophage (M1) or alternatively activated macrophage (M2) to respond to environmental stimuli. Signal transducer and activator of transcription 1 (STAT1), a
Xiaoxiao Zhu, Xiaoxiao Zhu, Xiaoxiao Zhu, Qiang Guo, Qiang Guo, Qiang Guo, Jing Zou, Bin Wang, Zhen Zhang, Zhen Zhang, Zhen Zhang, Ran Wei, Ran Wei, Ran Wei, Lin Zhao, Lin Zhao, Lin Zhao, Yunhong Zhang, Yunhong Zhang, Chu Chu, Chu Chu, Xiaoxiao Fu, Xiaoxiao Fu, Xia Li, Xia Li, Xia Li   +25 more
doaj   +1 more source