Results 21 to 30 of about 4,528,685 (232)

Regulated nuclear import of the STAT1 transcription factor by direct binding of importin‐α [PDF]

The EMBO Journal, 2002
Signal transducers and activators of transcription (STATs) reside in a latent state in the cytoplasm of the cell, but accumulate in the nucleus in response to cytokines or growth factors. Localization in the nucleus occurs following STAT tyrosine phosphorylation and dimerization.
Kevin M, McBride, Gregg, Banninger, Christine, McDonald, Nancy C, Reich   +3 more
openaire   +2 more sources

Variable structure motifs for transcription factor binding sites [PDF]

, 2010
Background: Classically, models of DNA-transcription factor binding sites (TFBSs) have been based on relatively few known instances and have treated them as sites of fixed length using position weight matrices (PWMs).
Evans, Kenneth J., Dyer, N., Nigel Dyer, Ott Sascha, Reid, J.E., Lorenz Wernisch, Sascha Ott, Ott, S., Wernisch Lorenz, John E Reid, Evans Kenneth J, Wernisch, Lorenz, Reid, J. E. (John E.), Kenneth J Evans, Dyer, Nigel, Dyer Nigel, Ott, Sascha, Reid John E   +17 more
core   +6 more sources

New and Inherited STAT1 Mutations in a Chinese Family with Chronic Mucocutaneous Candidiasis: A Case Report

Iranian Journal of Public Health, 2020
A mild clinical Chronic Mucocutaneous Candidiasis (CMC) phenotype with STAT1 transcription factor mutation has been identified in a Chinese family. It is a rare variant in STAT1 (NM_0073315.3c.1175T>C Met392Thr).
Xiaoheng XU, Wenxia MENG, Lu FENG, Wei GUO   +3 more
doaj   +1 more source

Nuclear factor I genomic binding associates with chromatin boundaries [PDF]

, 2013
BACKGROUND: The Nuclear Factor I (NFI) family of DNA binding proteins (also called CCAAT box transcription factors or CTF) is involved in both DNA replication and gene expression regulation.
Armelle Gaussin, Schmid, Christoph D., Mermod, Nicolas, Jozef Adamcik, Ambrosini, Giovanna, Schmid, C. D., Pjanic, P., Giovanna Ambrosini, Plasari, Genta, Genta Plasari, Bucher, P., Adamcik, Jozef, Kerschgens, J., Christoph D Schmid, Petar Pjanic, Pjanic, Petar, Kerschgens, Jan, Ambrosini, G., Pjanic, Milos, Gaussin, Armelle, Gaussin, A., Pjanic, M., Philipp Bucher, Plasari, G., Jan Kerschgens, Adamcik, J., Giovani Dietler, Bucher, Philipp, Milos Pjanic, Dietler, Giovani, Dietler, G., Schmid, C.D., Nicolas Mermod, Mermod, N.   +33 more
core   +2 more sources

STAT1 deficiency predisposes to spontaneous otitis media.

PLoS ONE, 2020
Signal transducer and activator of transcription 1 (STAT1) is known to be an important player in inflammatory responses. STAT1 as a transcription factor regulates the expression of multiple proinflammatory genes.
Daniel Bodmer, Peter Kern, David Bächinger, Arianne Monge Naldi, Soledad Levano Huaman   +4 more
doaj   +2 more sources

Alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains

Neuroscience Letters, 1997
Recent studies suggest that inflammatory activation occurs in the brains of patients with Alzheimer's disease (AD). Several transcription factors such as nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-1 (STAT1) may be activated in glial cells by a number of cytokines and then translocated from the cytosol to the ...
Y, Kitamura, S, Shimohama, T, Ota, Y, Matsuoka, Y, Nomura, T, Taniguchi   +5 more
openaire   +2 more sources

Transcription factor KLF4 regulated STAT1 to promote M1 polarization of macrophages in rheumatoid arthritis

Aging, 2022
This study aimed to reveal the mechanism of transcription factor Kruppel-like factor 4 (KLF4) in regulating M1 polarization of macrophages in rheumatoid arthritis (RA) in order to induce inflammatory response. The results suggested that KLF4 overexpression promoted the M1 polarization of RAW 264.7 cells, increased STAT1 expression and up-regulated the ...
Ye, Qiao, Luo, Fang, Yan, Tingting
openaire   +2 more sources

The effect of interferon on the transcription pattern of parainfluenza virus 5 [PDF]

, 2013
Interferon (IFN) is activated in response to virus infections and upregulates interferon-stimulated genes (ISGs) resulting in the expression of hundreds of proteins, many of which have direct or indirect antiviral activity.
Norsted, Hanna
core   +2 more sources

Macrophage-Derived Factors with the Potential to Contribute to Pathogenicity of HIV-1 and HIV-2: Role of CCL-2/MCP-1

Viruses, 2023
Human immunodeficiency virus type 2 (HIV-2) is known to be less pathogenic than HIV-1. However, the mechanism(s) underlying the decreased HIV-2 pathogenicity is not fully understood. Herein, we report that β-chemokine CCL2 expression was increased in HIV-
Chunling Gao, Weiming Ouyang, Joseph Kutza, Tobias A. Grimm, Karen Fields, Carla S. R. Lankford, Franziska Schwartzkopff, Mark Paciga, Tzanko Stantchev, Linda Tiffany, Klaus Strebel, Kathleen A. Clouse   +11 more
doaj   +1 more source

Bayesian model-based inference of transcription factor activity [PDF]

, 2007
<b>Background:</b> In many approaches to the inference and modeling of regulatory interactions using microarray data, the expression of the gene coding for the transcription factor is considered to be an accurate surrogate for the true ...
Rogers, S, Girolami, M, Rogers, Simon, Girolami, Mark, Khanin, R, Khanin, Raya   +5 more
core   +1 more source