CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response [PDF]
Immunity, 2013 Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation occurs upon promoter binding by an unknown kinase.
Bancerek, Joanna +10 more
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Transcription factor ZBP-89 is required for STAT1 constitutive expression [PDF]
Nucleic Acids Research, 2003 IFNgamma is a pro-inflammatory cytokine that potentiates p53-independent apoptosis in a variety of cell types. STAT1 is the primary mediator of IFNgamma action. ZBP-89 is a transcription factor that binds to the G/C-rich elements and mediates p53-independent apoptosis. In this study, site-directed mutagenesis revealed that a G-rich element from +171 to
Longchuan, Bai, Juanita L, Merchant
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Alteration of transcription factors NF-κB and STAT1 in Alzheimer's disease brains
Neuroscience Letters, 1997 Recent studies suggest that inflammatory activation occurs in the brains of patients with Alzheimer's disease (AD). Several transcription factors such as nuclear factor-kappaB (NF-kappaB) and signal transducer and activator of transcription-1 (STAT1) may be activated in glial cells by a number of cytokines and then translocated from the cytosol to the ...
Y, Kitamura +5 more
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Tumor STAT1 Transcription Factor Activity Enhances Breast Tumor Growth and Immune Suppression Mediated by Myeloid-derived Suppressor Cells [PDF]
Journal of Biological Chemistry, 2013 Previous studies had implicated the IFN-γ transcription factor signal transducer and activator of transcription 1 (STAT1) as a tumor suppressor. However, accumulating evidence has correlated increased STAT1 activation with increased tumor progression in multiple types of cancer, including breast cancer.
Laura M, Hix +5 more
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Trypanosoma cruzi evades the protective role of interferon-gamma-signaling in parasite-infected cells. [PDF]
PLoS ONE, 2014 The protozoan parasite Trypanosoma cruzi is responsible for the zoonotic Chagas disease, a chronic and systemic infection in humans and warm-blooded animals typically leading to progressive dilated cardiomyopathy and gastrointestinal manifestations.
Philipp Stahl +3 more
doaj +1 more source
Activated STAT1 Transcription Factors Conduct Distinct Saltatory Movements in the Cell Nucleus [PDF]
Biophysical Journal, 2011 The activation of STAT transcription factors is a critical determinant of their subcellular distribution and their ability to regulate gene expression. Yet, it is not known how activation affects the behavior of individual STAT molecules in the cytoplasm and nucleus.
Speil, Jasmin +5 more
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The DNA replication factor MCM5 is essential for Stat1-mediated transcriptional activation [PDF]
Proceedings of the National Academy of Sciences, 2005 The eukaryotic minichromosome maintenance (MCM) family of proteins (MCM2–MCM7) is evolutionarily conserved from yeast to human. These proteins are essential for DNA replication. The signal transducer and activator of transcription proteins are critical for the signal transduction of a multitude of cytokines and growth factors leading to the regulation ...
Marylynn, Snyder +2 more
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DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1 [PDF]
Genes & Development, 2003 Cytokine-dependent gene transcription greatly depends on the tyrosine phosphorylation (“activation”) of Stat proteins at the cell membrane. This rapidly leads to their accumulation in the nucleus by an unknown mechanism. We performed microinjections of recombinant Stat1 protein to show that nuclear accumulation of phosphorylated Stat1 can occur without
Meyer, Thomas +4 more
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Frontiers in Immunology, 2023 Talaromyces marneffei and Pneumocystis jirovecii are the common opportunistic pathogens in immunodeficient patients. There have been no reports of T. marneffei and P. jirovecii coinfection in immunodeficient children.
Qin Yang +11 more
doaj +1 more source
Loss of signal transducer and activator of transcription 1 is associated with prostate cancer recurrence [PDF]
, 2015 STAT1 loss has previously been implicated in cell line studies to modify prostate cancer cell growth and survival, however the clinical significance of this has not previously been established.
Edwards, Joanne +6 more
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