Results 11 to 20 of about 4,528,685 (232)

DNA binding controls inactivation and nuclear accumulation of the transcription factor Stat1 [PDF]

Genes & Development, 2003
Cytokine-dependent gene transcription greatly depends on the tyrosine phosphorylation (“activation”) of Stat proteins at the cell membrane. This rapidly leads to their accumulation in the nucleus by an unknown mechanism. We performed microinjections of recombinant Stat1 protein to show that nuclear accumulation of phosphorylated Stat1 can occur without
Thomas, Meyer, Andreas, Marg, Petra, Lemke, Burkhard, Wiesner, Uwe, Vinkemeier   +4 more
openaire   +3 more sources

Gene Activation by the Cytokine-Driven Transcription Factor STAT1

, 2019
Signal transducers and activators of transcription (STATs) are a family of cytokine-regulated transcription factors, which serve the dual role of external signal transduction and transcriptional activation. The founding member of this family, STAT1, is involved in a plethora of cellular processes, including interferon-dependent upregulation of various ...
Nast, Roswitha, Staab, Julia, Meyer, Thomas, Behzadi, Payam   +3 more
openaire   +4 more sources

STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma

Cancer Management and Research, 2018
Zhaoyong Liu,1,* Ying Zhang,2,* Yelong Chen,1 Youbin Lin,1 Zhen Lin,2 Hu Wang1 1Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; 2Department of Pathology, Shantou University ...
Liu Z, Zhang Y, Chen Y, Lin Y, Lin Z, Wang H   +5 more
doaj   +1 more source

Unusual Talaromyces marneffei and Pneumocystis jirovecii coinfection in a child with a STAT1 mutation: A case report and literature review

Frontiers in Immunology, 2023
Talaromyces marneffei and Pneumocystis jirovecii are the common opportunistic pathogens in immunodeficient patients. There have been no reports of T. marneffei and P. jirovecii coinfection in immunodeficient children.
Qin Yang, Chendi Yu, Yue Wu, Ke Cao, Xiaonan Li, Weiguo Cao, Lichao Cao, Shenrui Zhang, Ying Ba, Yuejie Zheng, Hezi Zhang, Wenjian Wang   +11 more
doaj   +1 more source

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response [PDF]

Immunity, 2013
Gene regulation by cytokine-activated transcription factors of the signal transducer and activator of transcription (STAT) family requires serine phosphorylation within the transactivation domain (TAD). STAT1 and STAT3 TAD phosphorylation occurs upon promoter binding by an unknown kinase.
Bancerek, Joanna, Poss, Zachary C., Steinparzer, Iris, Sedlyarov, Vitaly, Pfaffenwimmer, Thaddäus, Wiesauer, Ivana, Dölken, Lars, Strobl, Birgit, Müller, Mathias, Taatjes, Dylan J., Kovarik, Pavel   +10 more
openaire   +2 more sources

Cellular responses mediated by the transcription factor STAT1 in murine inflammatory diseases [PDF]

, 2022
The intracellular transduction of interferon signals from the plasma membrane to the nucleus is mediated by signal transducer and activator of transcription 1 (STAT1) which acts in tetrameric form as a transcription factor in immune responses. In this project, the protomer exchange between STAT1 dimers was studied under kinetic aspects and this process
Riebeling, Theresa, Meyer, Thomas, Georg-August-Universität Göttingen, Lutz, Susanne, Katschinski, Dörthe   +4 more
openaire   +2 more sources

Increased STAT1 signaling in endocrine-resistant breast cancer [PDF]

, 2014
Funding: China Scholarship Council, University of Edinburgh, Scottish Funding Council and Breakthrough Breast Cancer.Proteomic profiling of the estrogen/tamoxifen-sensitive MCF-7 cell line and its partially sensitive (MCF-7/LCC1) and fully resistant (MCF-
Thomas Jeremy S., Faratian Dana, Huang Rui, Sims Andrew H., Dana Faratian (171110), Simon P. Langdon, Danielle Wilson (550968), David J. Harrison (171106), Jeremy S. Thomas, Dana Faratian, Rui Huang, Wilson Danielle, Harrison David J., David J. Harrison, Danielle Wilson, Simon P Langdon, Thomas, Jeremy S, Sims, Andrew H, Andrew H. Sims (108040), Harrison, David J, Rui Huang (141490), Huang, Rui, Simon P. Langdon (207293), Wilson, Danielle, David J Harrison, Thomas, Jeremy, Langdon Simon P., Faratian, Dana, Andrew H. Sims, Andrew H Sims, Jeremy S Thomas, Jeremy S. Thomas (550969), Langdon, Simon P   +32 more
core   +2 more sources

Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. [PDF]

PLoS ONE, 2008
Inactivation of p27 Kip1 is implicated in tumorigenesis and has both prognostic and treatment-predictive values for many types of human cancer. The transcription factor Stat1 is essential for innate immunity and tumor immunosurveillance through its ...
Shuo Wang, Jennifer F Raven, Joan E Durbin, Antonis E Koromilas   +3 more
doaj   +1 more source

Activated STAT1 Transcription Factors Conduct Distinct Saltatory Movements in the Cell Nucleus [PDF]

Biophysical Journal, 2011
The activation of STAT transcription factors is a critical determinant of their subcellular distribution and their ability to regulate gene expression. Yet, it is not known how activation affects the behavior of individual STAT molecules in the cytoplasm and nucleus.
Speil, Jasmin, Baumgart, Eugen, Siebrasse, Jan-Peter, Veith, Roman, Vinkemeier, Uwe, Kubitscheck, Ulrich   +5 more
openaire   +2 more sources

Signal transducer and activator of transcription-1 localizes to the mitochondria and modulates mitophagy [PDF]

, 2013
The signal transducer and activator of transcription (STAT) proteins are latent transcription factors that have been shown to be involved in cell proliferation, development, apoptosis, and autophagy. STAT proteins undergo activation by phosphorylation at
Stephanou, A., McCormick, J., Latchman, David S., Knight, R,A,, Bourke, L.T.   +4 more
core   +1 more source