Results 1 to 10 of about 70,913 (119)

Indonesian River Buffalo Molecular Phylogeny Compared to Other Mammals Based on STAT1 Sequence

Jurnal Agripet, 2022
. Genes differ in sequence, size, and functional domains among species. According to studies, STAT1 provides information on the rate of evolution that correlates with its function in the immune system.
Fuad Hasan, Armyn Hakim Daulay, Ferdy Saputra, Isyana Khaerunnisa   +3 more
doaj   +1 more source

Effects of flavonoids from Allium mongolicum Regel on cell apoptosis, cell cycle and STAT1 mRNA expression in peripheral blood lymphocytes of sheep

Journal of Applied Animal Research, 2021
Flavonoids from Allium mongolicum Regel (AMR) have immunoregulatory and anti-inflammatory properties. However, the effect of flavonoids from A. mongolicum Regel on sheep peripheral blood lymphocytes is still unknown.
Mu Qie, Terigele Wang, manda, Changjin Ao   +3 more
doaj   +1 more source

Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism

Viruses, 2020
Persistent infection by human papillomaviruses (HPVs), small, double-stranded DNA viruses that infect keratinocytes of the squamous epithelia, can lead to the development of cervical and other cancers.
Sadie Rice, Seong-man Kim, Cynthia Rodriguez, William Songock, Gaurav Raikhy, Rebecca Lopez, Lauren Henderson, Arjun Yusufji, Jason Bodily   +8 more
doaj   +1 more source

Ube2L6 Promotes M1 Macrophage Polarization in High-Fat Diet-Fed Obese Mice via ISGylation of STAT1 to Trigger STAT1 Activation

Obesity Facts, 2023
Introduction: In obesity-related type 2 diabetes mellitus (T2DM), M1 macrophages aggravate chronic inflammation and insulin resistance. ISG15-conjugation enzyme E2L6 (Ube2L6) has been demonstrated as a promoter of obesity and insulin resistance.
Yunqian Li, Xiao Dong, Wenqian He, Huibiao Quan, Kaining Chen, Chaoping Cen, Weiping Wei   +6 more
doaj   +1 more source

Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2

Virulence, 2021
The Interferon (IFN) response is crucial to restrain pathogenic infections. Investigations into flavivirus-host interactions reported that the high virulence is linked to innate immune evasion.
Elisa Fanunza, Fabrizio Carletti, Marina Quartu, Nicole Grandi, Laura Ermellino, Jessica Milia, Angela Corona, Maria Rosaria Capobianchi, Giuseppe Ippolito, Enzo Tramontano   +9 more
doaj   +1 more source

BST2 regulates interferon gamma-dependent decrease in invasion of HTR-8/SVneo cells via STAT1 and AKT signaling pathways and expression of E-cadherin

Cell Adhesion & Migration, 2020
The mechanism by which interferon-gamma (IFN-γ) downregulates trophoblast invasion needs further investigation. Treatment of HTR-8/SVneo cells with IFN-γ led to a decrease in their invasion concomitant with an increased expression of BST2.
Sonam Verma, Amandeep Kaur Kang, Rahul Pal, Satish Kumar Gupta   +3 more
doaj   +1 more source

Genetic polymorphism of stat1 and stat5a genes in holstein, jersey, and indigenous cattle breeds in turkey [PDF]

Kafkas Universitesi Veteriner Fakültesi Dergisi, 2019
This study aimed to determine genetic polymorphism in STAT1 and STAT5A genes for dairy cattle and some native cattle breeds in Turkey. 283 Jersey and a total of 472 Holstein cows from two different herds and 93 Grey Steppe, 85 Anatolian Black Cattle, and
Ozden COBANOGLU, Ertugrul KUL, Samet Hasan ABACI, Eser Kemal GURCAN, Soner CANKAYA   +4 more
doaj   +1 more source

Immunomodulatory Effects of Ferula assa-foetida Extract on NF-κB and STAT1 Signaling Pathways in GM-CSF-Differentiated Human Macrophages [PDF]

Journal of Epigenetics
The immunomodulatory properties of Ferula assa-foetida, a perennial herb traditionally used for its anti-inflammatory effects, were investigated in this study, focusing on its influence on NF-κB and STAT1 signaling pathways in GM-CSF-differentiated human
Ali Abolhasanzadeh Parizi, Milad Lagzian
doaj   +1 more source

Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment [PDF]

Open Biology, 2016
Adipose tissue is a key determinant of whole-body metabolism and energy homeostasis. Unravelling the transcriptional regulatory process during adipogenesis is therefore highly relevant from a biomedical perspective.
Xiaoming Hu, Yuanfei Zhou, Yang Yang, Jie Peng, Tongxing Song, Tao Xu, Hongkui Wei, Siwen Jiang, Jian Peng   +8 more
doaj   +1 more source

An inhibitory effect on the nuclear accumulation of phospho-STAT1 by its unphosphorylated form

Cell Communication and Signaling, 2022
Background Unphosphorylated signal transducer and activator of transcription 1 (U-STAT1) has been reported to elicit a distinct gene expression profile as compared to tyrosine-phosphorylated STAT1 (P-STAT1) homodimers.
Priyanka Rajeev Menon, Julia Staab, Anke Gregus, Oliver Wirths, Thomas Meyer   +4 more
doaj   +1 more source