Results 1 to 10 of about 112,289 (303)
STAT1 Gain-of-Function Mutations Cause High Total STAT1 Levels With Normal Dephosphorylation [PDF]
Frontiers in Immunology, 2019 Signal transducer and activator of transcription (STAT1)1 gain of function (GOF) pathogenic variants have been associated with increased levels of phosphorylated STAT1 and STAT1-dependent cellular responses.
Ofer Zimmerman +14 more
doaj +4 more sources
ERK is a negative feedback regulator for IFN-γ/STAT1 signaling by promoting STAT1 ubiquitination [PDF]
BMC Cancer, 2018 Background We recently reported that STAT1 plays a tumor suppressor role, and ERK was inversely correlation with STAT1 expression in esophageal squamous cell carcinoma (ESCC).
Ying Zhang +3 more
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STAT1 deficiency predisposes to spontaneous otitis media.
PLoS ONE, 2020 Signal transducer and activator of transcription 1 (STAT1) is known to be an important player in inflammatory responses. STAT1 as a transcription factor regulates the expression of multiple proinflammatory genes.
Daniel Bodmer +4 more
doaj +6 more sources
STAT1 drives M1 macrophage polarization during Aspergillus fumigatus infection [PDF]
European Journal of Medical ResearchBackground Macrophages exhibit distinct polarization states (M1/M2) in response to inflammatory stimuli. However, the molecular mechanisms regulating macrophage polarization during Aspergillus fumigatus infection remain incompletely understood. Objective
Wenjun Wang +3 more
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Indonesian River Buffalo Molecular Phylogeny Compared to Other Mammals Based on STAT1 Sequence
Jurnal Agripet, 2022 . Genes differ in sequence, size, and functional domains among species. According to studies, STAT1 provides information on the rate of evolution that correlates with its function in the immune system.
Fuad Hasan +3 more
doaj +1 more source
Cancer Research, 2004 Abstract The anthracyclines, such as doxorubicin, are widely used in the treatment of breast cancer. Previously, we showed that these drugs could activate the transcription factor, nuclear factor κB, in a DNA damage-dependent manner.
Michelle Thomas +6 more
openaire +1 more source
Journal of Applied Animal Research, 2021 Flavonoids from Allium mongolicum Regel (AMR) have immunoregulatory and anti-inflammatory properties. However, the effect of flavonoids from A. mongolicum Regel on sheep peripheral blood lymphocytes is still unknown.
Mu Qie +3 more
doaj +1 more source
Viruses, 2020 Persistent infection by human papillomaviruses (HPVs), small, double-stranded DNA viruses that infect keratinocytes of the squamous epithelia, can lead to the development of cervical and other cancers.
Sadie Rice +8 more
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Obesity Facts, 2023 Introduction: In obesity-related type 2 diabetes mellitus (T2DM), M1 macrophages aggravate chronic inflammation and insulin resistance. ISG15-conjugation enzyme E2L6 (Ube2L6) has been demonstrated as a promoter of obesity and insulin resistance.
Yunqian Li +6 more
doaj +1 more source
Zika virus NS2A inhibits interferon signaling by degradation of STAT1 and STAT2
Virulence, 2021 The Interferon (IFN) response is crucial to restrain pathogenic infections. Investigations into flavivirus-host interactions reported that the high virulence is linked to innate immune evasion.
Elisa Fanunza +9 more
doaj +1 more source