Results 41 to 50 of about 82,953 (296)
Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells [PDF]
, 2009 This work was supported by the Wellcome Trust.Although the replication cycle of parainfluenza virus type 5 (PIV5) is initially severely impaired in cells in an interferon (IFN)-induced antiviral state, the virus still targets STAT1 for degradation.
Carlos, T S +4 more
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Aortic calcification in a patient with a STAT1 mutation
Annals of Pediatric CardiologyChronic mucocutaneous candidiasis (CMC) is a condition characterized by persistent or recurrent infections caused by candida species. Gain-of-function (GOF) mutations in signal transducer and activator of transcription-1 (STAT1) have been identified as a
Gamze Sonmez +3 more
doaj +1 more source
Quantitative specificity of STAT1 and several variants [PDF]
Nucleic Acids Research, 2017 The quantitative specificity of the STAT1 transcription factor was determined by measuring the relative affinity to hundreds of variants of the consensus binding site including variations in the length of the site. The known consensus sequence is observed to have the highest affinity, with all variants decreasing binding affinity considerably. There is
Basab Roy, Zheng Zuo, Gary D. Stormo
openaire +3 more sources
Novel STAT1 alleles in otherwise healthy patients with mycobacterial disease. [PDF]
PLoS Genetics, 2006 The transcription factor signal transducer and activator of transcription-1 (STAT1) plays a key role in immunity against mycobacterial and viral infections.
Ariane Chapgier +21 more
doaj +1 more source
, 2019 Age- and sex-matched Stat1+/- and Stat1-/- littermates were infected with 10/ PFU of UV-inactivated (UV) or live MNV via oral gavage. At 3 days post-infection ileum, Peyer`s patches (PP), mesenteric lymph nodes (MLN), spleen and liver lysates were ...
Frederic Sorgeloos (5659216) +9 more
core +1 more source
PLoS Pathogens, 2016 STAT1 is a critical transcription factor for regulating host antiviral defenses. STAT1 activation is largely dependent on phosphorylation at tyrosine 701 site of STAT1 (pY701-STAT1).
Ying Ren +16 more
doaj +1 more source
Immunoprofiling of monocytes in STAT1 gain-of-function chronic mucocutaneous candidiasis
Frontiers in Immunology, 2022 Patients with STAT1 gain-of-function (GOF) mutations suffer from an inborn error of immunity hallmarked by chronic mucocutaneous candidiasis (CMC). The pathogenesis behind this complex and heterogeneous disease is still incompletely understood.
Marketa Bloomfield +5 more
doaj +1 more source
Regulation of STAT1 Nuclear Export by Jak1 [PDF]
Molecular and Cellular Biology, 2000 Signal transducer and activator of transcription 1 (STAT1) mediates gene expression in response to cytokines and growth factors. Activation of STAT1 is achieved through its tyrosine phosphorylation, a process that involves Jak tyrosine kinases. Here we show that STAT1, although phosphorylated on Y701, is unable to localize in the nucleus in the absence
K, Mowen, M, David
openaire +2 more sources
STAT1 pathway mediates amplification of metastatic potential and resistance to therapy. [PDF]
PLoS ONE, 2009 Traditionally IFN/STAT1 signaling is connected with an anti-viral response and pro-apoptotic tumor-suppressor functions. Emerging functions of a constitutively activated IFN/STAT1 pathway suggest an association with an aggressive tumor phenotype.
Nikolai N Khodarev +13 more
doaj +1 more source
, 2022 Antagonism of the interferon (IFN)-mediated antiviral state is critical to infection by rabies virus (RABV) and other viruses, and involves interference in the IFN induction and signaling pathways in infected cells, as well as deactivation of the ...
Michelle D Audsley +26 more
core +1 more source