Results 61 to 70 of about 112,289 (303)

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

OROPHARYNGEAL ADMINISTRATION OF POLYSTYRENE MICROPLASTICS INDUCES PROFIBROTIC AND OXIDATIVE CHANGES IN MURINE LUNG TISSUE

Проблеми екології та медицини
Aim: This study investigated the early pulmonary effects of intratracheally administered polystyrene microplastics (PS-MPs) in mice. Recognizing the emerging health concern of atmospheric microplastic inhalation, the research focused on identifying ...
Ye.V. Rybalchenko, A.V. Kabaliei, V.V. Palchyk, V.I. Shynkevych, I.P. Kaidashev   +4 more
doaj   +1 more source

A chemical probe inhibitor targeting STAT1 restricts cancer stem cell traits and angiogenesis in colorectal cancer

Journal of Biomedical Science, 2022
Background Colorectal cancer (CRC) is a worldwide cancer with rising annual incidence. New medications for patients with CRC are still needed. Recently, fluorescent chemical probes have been developed for cancer imaging and therapy. Signal transducer and
Pei-Hsuan Chou, Cong-Kai Luo, Niaz Wali, Wen-Yen Lin, Shang-Kok Ng, Chun-Hao Wang, Mingtao Zhao, Sheng-Wei Lin, Pei-Ming Yang, Pin-Jung Liu, Jiun-Jie Shie, Tzu-Tang Wei   +11 more
doaj   +1 more source

Regulation of STAT1 Nuclear Export by Jak1 [PDF]

Molecular and Cellular Biology, 2000
Signal transducer and activator of transcription 1 (STAT1) mediates gene expression in response to cytokines and growth factors. Activation of STAT1 is achieved through its tyrosine phosphorylation, a process that involves Jak tyrosine kinases. Here we show that STAT1, although phosphorylated on Y701, is unable to localize in the nucleus in the absence
K, Mowen, M, David
openaire   +2 more sources

Methods for detection and characterization of signals in noisy data with the Hilbert-Huang Transform

, 2009
The Hilbert-Huang Transform is a novel, adaptive approach to time series analysis that does not make assumptions about the data form. Its adaptive, local character allows the decomposition of non-stationary signals with hightime-frequency resolution but ...
Alexander Stroeer, B. Silverman, C. W. Helstrom, John K. Cannizzo, Jordan B. Camp, N. Huang, Nicolas Gagarin, Z. Wu   +7 more
core   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Inhibition of STAT1 accelerates bone fracture healing [PDF]

Journal of Orthopaedic Research, 2010
AbstractSkeletal fracture healing involves a variety of cellular and molecular events; however, the mechanisms behind these processes are not fully understood. In the current study, we investigated the potential involvement of the signal transducer and activator of transcription 1 (STAT1), a critical regulator for both osteoclastogenesis and osteoblast
Kosuke, Tajima, Hironari, Takaishi, Jiro, Takito, Takahide, Tohmonda, Masaki, Yoda, Norikazu, Ota, Naoto, Kosaki, Morio, Matsumoto, Hiroyasu, Ikegami, Toshiyasu, Nakamura, Tokuhiro, Kimura, Yasunori, Okada, Keisuke, Horiuchi, Kazuhiro, Chiba, Yoshiaki, Toyama   +14 more
openaire   +2 more sources

Intracellular interferons in fish : a unique means to combat viral infection [PDF]

, 2013
Peer reviewedPublisher ...
A Lopez-Munoz, A Matsuo, A Pindel, AJ Sadler, B Sun, Bei Huang, Bertrand Collet, C Stein, Chris J. Secombes, CM Ahmed, D Aggad, E Kalie, EL Ooi, F Sun, FF Yu, J Zou, J Zou, J Zou, J Zou, JM Gonzalez-Navajas, Jun Zou, Karen L. Mossman, KE Taylor, M Chang, M Shin-Ya, Ming-Xian Chang, MK Purcell, N Sathish, O Haller, OJ Hamming, PE Phelan, Pin Nie, S Biacchesi, S Campbell, S Long, S Long, SA Martin, SV Kotenko, SY Liu, T Svingerud, V Bergan, Y Palti, YB Zhang, Z Li, Z Qi, Zhanglong Yu   +45 more
core   +3 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source