Results 81 to 90 of about 82,953 (296)
Novel function of STAT1 in breast cancer [PDF]
OncoImmunology, 2013 In the past, the transcription factor STAT1 was considered as a tumor suppressor. We have recently discovered that STAT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloid-derived suppressor cells (MDSCs).
openaire +2 more sources
SH2 modified STAT1 induces HLA-I expression and improves IFN-γ signaling in IFN-α resistant HCV replicon cells. [PDF]
PLoS ONE, 2010 We have developed multiple stable cell lines containing subgenomic HCV RNA that are resistant to treatment with interferon alpha (IFN-α. Characterization of these IFN-α resistant replicon cells showed defects in the phosphorylation and nuclear ...
Bret Poat +6 more
doaj +1 more source
Advanced Science, EarlyView.Disturbed flow promotes the formation of TRIM21‐rich biomolecular droplets, which concentrate TRIM21 and PTPN14 and facilitate their SPRY‐FERM interaction (illustrated by the TRIM21 D355‐PTPN14 R132 salt bridge). This condensate‐driven proximity enables TRIM21 to catalyze K48‐linked polyubiquitination of PTPN14 at lysine 956, leading to proteasome ...
Xue He +10 more
wiley +1 more source
ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells
Cancer Management and Research, 2020 Zhi Wang,1,2 Laura E Pascal,2 Uma R Chandran,3 Srilakshmi Chaparala,3 Shidong Lv,2,4 Hui Ding,2 Lin Qi,1 Zhou Wang2,5– 7 1Department of Urology, Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Department ...
Wang Z +7 more
doaj
Selective Modulation of OTUB1 Noncanonical Function via a bioPhosTAC Strategy
Advanced Science, EarlyView.This work positions the versatile performance of the peptide‐based bioPhosTAC platform for dissecting phosphorylation‐dependent biology and expanding the scope of induced‐proximity technologies. We demonstrated that selective manipulation of a tyrosine phosphorylation site is sufficient to propagate coordinated cellular consequences.
Seung Un Seo +7 more
wiley +1 more source
Molecular Medicine, 2023 Background Myelin sheath is a crucial accessory to the functional nerve-fiber unit, its disruption or loss can lead to axonal degeneration and subsequent neurodegenerative diseases (NDs).
Jinghui Xu +13 more
doaj +1 more source
Investigating the role of the JAK/STAT and MAPK pathways in ischaemia/reperfusion injury and inflammation [PDF]
, 2009 The signal transducer and activator of transcription (STAT) proteins are a family of transcription factors which transduce extracellular signals from cytokines, growth factors and G-proteins to the nucleus.
Barry, S.P.
core
Advanced Science, EarlyView.A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo +10 more
wiley +1 more source
TRAF6 is a nexus for TLR‐STAT1 crosstalk [PDF]
Immunology & Cell Biology, 2014 Cells communicate with their extracellular environment via cell surface receptors. Cytokine receptors are a class of transmembrane receptors that recognize cognate cytokines (for example, interferons (IFNs)) released by other cells and transmit this information into the cell via signal transduction circuits involving receptor-associated Janus Kinase ...
Bezbradica, JS, Schroder, K
openaire +5 more sources
Loss of STAT1 from Mouse Mammary Epithelium Results in an Increased Neu-Induced Tumor Burden
Neoplasia: An International Journal for Oncology Research, 2010 Type I and type II classes of interferons (IFNs) signal through the JAK/STAT1 pathway and are known to be important in adaptive and innate immune responses and in protection against tumors.
Peter J. Klover +5 more
doaj +1 more source