Results 81 to 90 of about 112,289 (303)

Unsupervised Bayesian linear unmixing of gene expression microarrays [PDF]

, 2013
Background: This paper introduces a new constrained model and the corresponding algorithm, called unsupervised Bayesian linear unmixing (uBLU), to identify biological signatures from high dimensional assays like gene expression microarrays. The basis for
A Hyvärinen, Aimee K Zaas, AK Zaas, Alfred O Hero III, B Chen, CM Carvalho, CP Robert, Cécile Bazot, D Dueck, DD Lee, EJ Fertig, Geoffrey S Ginsburg, GJ McLachlan, J Baek, J Paisley, Jean-Yves Tourneret, JM Nascimento, KY Yeung, M West, ME Winter, N Dobigeon, N Dobigeon, Nicolas Dobigeon, P Fogel, PJ Green, RO Duda, TD Moloshok, TF Cox, V Nikulin, WR Gilks, Y Huang   +30 more
core   +4 more sources

Bifidobacterium Pseudolongum‐Derived Acetate Attenuates Acute Pancreatitis Through GPR43‐Mediated Suppression of M1 Macrophage Polarization

Advanced Science, EarlyView.
The severity of acute pancreatitis (AP) is linked to reduced abundance of Bifidobacterium pseudolongum (B. pseudolongum). Administration of B. pseudolongum or its key metabolite acetate alleviates pancreatic and systemic inflammation by suppressing M1 macrophage polarization.
Langyi Guan, Xueyang Li, Cong He, Pan Zheng, Yaoyu Zou, Qi Zhu, Xin Li, Jie Liang, Junmin Yang, Li Zhang, Yuman Ye, Jianhua Wan, Huajing Ke, Jianping Liu, Nonghua Lu, Nianshuang Li, Yin Zhu   +16 more
wiley   +1 more source

Bidirectional Impact of Varying Severity of Acute Kidney Injury on Calcium Oxalate Stone Formation

Kidney & Blood Pressure Research
Introduction: Acute kidney injury (AKI) is a prevalent renal disorder. The occurrence of AKI may promote the formation of renal calcium oxalate stones by exerting continuous effects on renal tubular epithelial cells (TECs).
Yu Yang, Junkai Huang, Xiaochen Ma, Haijie Xie, Linguo Xie, Chunyu Liu   +5 more
doaj   +1 more source

Abnormal Mammary Development in 129:STAT1-Null Mice is Stroma-Dependent. [PDF]

PLoS ONE, 2015
Female 129:Stat1-null mice (129S6/SvEvTac-Stat1(tm1Rds) homozygous) uniquely develop estrogen-receptor (ER)-positive mammary tumors. Herein we report that the mammary glands (MG) of these mice have altered growth and development with abnormal terminal ...
Jane Q Chen, Hidetoshi Mori, Robert D Cardiff, Josephine F Trott, Russell C Hovey, Neil E Hubbard, Jesse A Engelberg, Clifford G Tepper, Brandon J Willis, Imran H Khan, Resmi K Ravindran, Szeman R Chan, Robert D Schreiber, Alexander D Borowsky   +13 more
doaj   +1 more source

Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]

, 2017
The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J., Cumberworth, Stephanie, Donald, Claire L., Kohl, Alain   +3 more
core   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

A time- and dose-dependent STAT1 expression system

BMC Biotechnology, 2006
Background The signal transducer and activator of transcription (STAT) family of transcription factors mediates a variety of cytokine dependent gene regulations.
Painz Ronald, Bokor Marion, Strobl Birgit, Leitner Nicole R, Kolbe Thomas, Rülicke Thomas, Müller Mathias, Karaghiosoff Marina   +7 more
doaj   +1 more source

Distal regulatory element of theSTAT1gene potentially mediates positive feedback control of STAT1 expression [PDF]

Genes to Cells, 2015
We previously identified a distal regulatory element located approximately 5.5‐kb upstream of the signal transducer and activator of transcription 1 (STAT1) gene, thereafter designating it as 5.5‐kb upstream regulatory region (5.5URR). In this study, we investigated the functional roles of 5.5URRin the transcriptional regulation ofSTAT1gene.
Katsutoshi, Yuasa, Takao, Hijikata
openaire   +2 more sources

Legumain Restrains Granuloma Formation by Inhibiting mTORC1/STAT1‐Mediated M1 Macrophage Polarization in Sarcoidosis

Advanced Science, EarlyView.
Legumain (LGMN) is upregulated in macrophages during sarcoid‑like granuloma formation. Macrophage‑derived LGMN binds to integrin αvβ3 and suppresses mTORC1/STAT1 signaling to restrain M1 macrophage polarization. Intratracheal delivery of lipid nanoparticles carrying Lgmn plasmid DNA (pDNA) elevates LGMN expression and effectively attenuates pulmonary ...
Mengyuan Liu, Yueyin Han, Bingbing Xie, Lili Zhu, Wenxiu Xu, Yinzhen Han, Yue Liao, Shuwei Gao, Dingyuan Jiang, Jing Geng, Zhen Li, Yinan Hu, Huaping Dai   +12 more
wiley   +1 more source

ELL2 Is Required for the Growth and Survival of AR-Negative Prostate Cancer Cells

Cancer Management and Research, 2020
Zhi Wang,1,2 Laura E Pascal,2 Uma R Chandran,3 Srilakshmi Chaparala,3 Shidong Lv,2,4 Hui Ding,2 Lin Qi,1 Zhou Wang2,5– 7 1Department of Urology, Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Department ...
Wang Z, Pascal LE, Chandran UR, Chaparala S, Lv S, Ding H, Qi L, Wang Z   +7 more
doaj