Results 101 to 110 of about 82,953 (296)
, 2016 (A) 293T cells were treated with IFNα (1,000 IU/ml) as indicated following with MG132 (10 μM) pretreatment for 1 hr. STAT1 proteins were immunoprecipitated and analyzed by indicated antibodies.
Yukang Yuan (2883881) +16 more
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STAT1 regulates p73-mediated Bax gene expression [PDF]
, 2007 Although signal transducer and activator of transcription 1 (STAT1) mediated regulation of p53 transcription and apoptosis has been previously reported, modulation of other members of the p53 family of transcription factors remains poorly understood.
Stephanou, A. +16 more
core +1 more source
Advanced Science, EarlyView.D4F‐functionalized ceria nanozyme–CasRx nanoparticles preferentially target renal macrophages through SR‐B1‐mediated uptake in ischemia–reperfusion injury. Ceria scavenges excessive ROS, while CasRx silences STING signaling, shifting macrophages toward a less inflammatory, pro‐resolving state and increasing the proportion of regulatory T cells.
Weibo Chen +11 more
wiley +1 more source
Intelligent Programmable Membrane Nanosponge for Early Virus Blocking
Advanced Science, EarlyView.A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen +17 more
wiley +1 more source
STAT1 inhibits STAT3 activation in esophageal squamous cell carcinoma
, 2018 Zhaoyong Liu,1,* Ying Zhang,2,* Yelong Chen,1 Youbin Lin,1 Zhen Lin,2 Hu Wang1 1Department of Orthopaedics, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China; 2Department of Pathology, Shantou University ...
Liu Z +5 more
core
Advanced Science, EarlyView.Sepsis triggers hippocampal SIRT7 loss, promoting histone H2B succinylation and activation of the PD‐1/PD‐L1–PINK1 axis. This metabolic‐epigenetic cascade drives aberrant mitophagy and neuronal injury, ultimately causing cognitive deficits. Targeting SIRT7‐dependent succinylation offers a potential strategy to protect brain function during sepsis ...
Na Meng +12 more
wiley +1 more source
Advanced Science, EarlyView.Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang +11 more
wiley +1 more source
ZOL downregulates STAT1 expression posttranscriptionally.
, 2013 A, baseline expression of STAT1 in RCC cell lines. Cell lysates from four untreated RCC cell lines (786-O, A-498, ACHN, and Caki-1) were subjected to western blot for STAT1 expression.
Kazunori Kihara (339824) +5 more
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Advanced Science, EarlyView.Glucocorticoids (GC) are widely used to reduce inflammation. We show that the glucocorticoid receptor in myeloid cells regulates macrophage cell cycle and genome integrity during muscle regeneration. We demonstrate that dexamethasone administration during the early inflammatory phase delays muscle repair by increasing macrophage proliferation ...
Sirine Souali‐Crespo +11 more
wiley +1 more source
Tyrosine 701-phosphorylated STAT1 and total STAT1 levels are higher in sHLH patient liver biopsies.
, 2019 A) Tyr(701)-phosphorylated STAT1 (pSTAT1) and total STAT1 protein levels were evaluated by Western Blot analyses in patient and control total liver lysates. B) pSTAT1 and STAT1 relative density values were reported.
Marco Spada (236228) +14 more
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