Results 111 to 120 of about 112,289 (303)

Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]

, 2012
Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P., Bozinovski, S., Ernst, M.R., Jarnicki, A.G., Jones, J., Knight, D.A., Lau, H.L., Laurent, G.J., McAnulty, R.J., McKenzie, B.S., Mutsaers, S.E., O'Donoghue, R.J.J., Prêle, C.M., Richards, C.D., Rose-John, S., Stumbles, P.A., Thiem, S., Vlahos, R., Wang, B., Zhu, H.J.   +19 more
core   +2 more sources

High‐Performance Prevascularized SHED‐Laden rGO@Hydrogel Achieves Optimized Diabetic Bone Defect Repair

Advanced Science, EarlyView.
A high‐performance 3D scaffold integrating rGO and SHEDs is developed to overcome impaired healing in diabetic bone defects. By driving extracellular matrix remodeling, rGO creates a pro‐angiogenic niche that significantly accelerates in vitro vascular network formation.
Can Zhang, Yiyuan Kang, Shulin Lai, Chunyi Wang, Guixin He, Kehui Jian, Suhan Yin, Xiner Tan, Xinru Zhou, Wenjing Liu, Fujian Zhao, Jia Liu, Longquan Shao   +12 more
wiley   +1 more source

Zika virus infection triggers caspase cleavage of STAT1

Microbiology Spectrum
Zika virus (ZIKV) is an important pathogen that causes Guillain-Barre syndrome in adults and congenital Zika syndrome in newborns. Interferon (IFN) triggers intracellular antiviral signaling through two essential mediators STAT1 and STAT2, which are ...
Jun Shu, Xiao Ma, Jingyi Zou, Zhenghong Yuan, Zhigang Yi   +4 more
doaj   +1 more source

STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I–Transformed and ATL Cells

Neoplasia: An International Journal for Oncology Research, 2015
We have previously reported on the deregulation of cellular microRNAs involved in hematopoiesis and inflammation in human T-cell lymphotropic virus type 1 (HTLV-I)–transformed cells.
Ramona Moles, Marcia Bellon, Christophe Nicot   +2 more
doaj   +1 more source

Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection [PDF]

, 2012
Infection with severe acute respiratory syndrome coronavirus (SARS-CoV) causes acute lung injury (ALI) that often leads to severe lung disease. A mouse model of acute SARS-CoV infection has been helpful in understanding the host response to infection ...
Bauer, Bromberg, Byers, Byers, C. Page, Clausen, Collard, Daley, Dasgupta, Ding, Durbin, Durbin, Eschrich, Franks, Frieman, Frieman, Gordon, Gross, Han, Hussain, Jakubzick, K. Matthews, Kaganoi, Khodarev, Kim, Klover, Kobasa, Kollef, Kopecky-Bromberg, Ksiazek, Kuiken, Kurowska-Stolarska, L. Goicochea, L. Hennighausen, Lau, Lee, Levy, Liddiard, Lillemeier, Lopez-Navarrete, M. Frieman, M. J. Holtzman, Mauad, Meduri, Meneghin, Meraz, Mishra, Mora, Moreira, Moreno, Narayanan, Netland, Ohtsubo, P. Klover, Pechkovsky, Peiris, Perrone, Pesce, Pierce, Pierrakos, Raes, Raes, Reiman, Roberts, Rock, Rodriguez-Sosa, Saleh, Schafer, Schindler, Shornick, Sims, Spiegel, Stein, Stolfi, Subrata, Sun, Walters, Watanabe, Wathelet, Wong, Wynn, Wynn, Y. Zhang, Yu, Zhang, Zhao, Zornetzer   +86 more
core   +2 more sources

Dissecting Pirtobrutinib Resistance in Mantle Cell Lymphoma Through Single‐Cell Multi‐Omics

American Journal of Hematology, EarlyView.
ABSTRACT Pirtobrutinib (PBN), a non‐covalent BTK inhibitor, has been approved by the FDA for relapsed/refractory mantle cell lymphoma (MCL); however, resistance to PBN has been observed. To dissect the molecular dynamics driving PBN resistance, we performed integrative single‐cell multi‐omic profiling (scRNA‐seq, scATAC‐seq, and scDNA‐seq) on ...
Fangfang Yan, Yang Liu, Heng‐Huan Lee, Wei Wang, Joseph McIntosh, Yijing Li, Jovanny Vargas, Yue Fei, Sairah Ahmed, Lukas M. Simon, Michael Wang   +10 more
wiley   +1 more source

DJ-1 facilitates the interaction between STAT1 and its phosphatase, SHP-1, in brain microglia and astrocytes: A novel anti-inflammatory function of DJ-1

Neurobiology of Disease, 2013
Parkinson’s disease (PD) is a progressive neurodegenerative movement disorder caused by the death of dopaminergic neurons in the substantia nigra. Importantly, altered astrocyte and microglial functions could contribute to neuronal death in PD.
Jong-hyeon Kim, Dong-joo Choi, Hey-kyeong Jeong, Jun Kim, Dae Won Kim, Soo Young Choi, Sang-Myun Park, Young Ho Suh, Ilo Jou, Eun-Hye Joe   +9 more
doaj   +1 more source

STAT1 negatively regulates hepatocellular carcinoma cell proliferation

Oncology Reports, 2013
Signal transducer and activator of transcription 1 (STAT1) regulates cell proliferation and survival. The present study aimed to investigate the role of STAT1 in the development and progression of human hepatocellular carcinoma (HCC). The levels of STAT1 expression in 36 HCC and 12 non-HCC liver tissues were examined by immunohistochemistry. The effect
Guofu, Chen, Haihe, Wang, Shuli, Xie, Jian, Ma, Guangyi, Wang   +4 more
openaire   +3 more sources

Erythropoietin-induced serine 727 phosphorylation of STAT3 in erythroid cells is mediated by a MEK-, ERK-, and MSK1-dependent pathway [PDF]

, 2003
Objective. Erythropoietin (EPO) is a key regulator of erythropoiesis, playing a role in both the proliferation and differentiation of erythroid cells.
Bieber, Boer, Chung, Decker, Gabrilove, Gonzalez, Goodnough, Gotoh, Haq, Jain, Jain, Jonk, Kaptein, Kirito, Kirito, Kirito, Lim, Millot, Miyazaki, Mulcahy, Ng, Schuringa, Schuringa, Schuringa, Smithgall, Socolovsky, Teglund, Tilbrook, Turkson, Watowich, Wen, Wen, Woetmann, Yokogami, Youssoufian, Yu, Zhang   +36 more
core   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source