Results 111 to 120 of about 82,953 (296)

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Zika virus infection triggers caspase cleavage of STAT1

Microbiology Spectrum
Zika virus (ZIKV) is an important pathogen that causes Guillain-Barre syndrome in adults and congenital Zika syndrome in newborns. Interferon (IFN) triggers intracellular antiviral signaling through two essential mediators STAT1 and STAT2, which are ...
Jun Shu, Xiao Ma, Jingyi Zou, Zhenghong Yuan, Zhigang Yi   +4 more
doaj   +1 more source

USP12 maintains nuclear p-STAT1 levels by blocking acetylation and subsequent dephosphorylation of p-STAT1 in the nucleus.

, 2020
(A) Immunoprecipitation analysis of STAT1 acetylation in the nucleus of RAW264.7 cells cotransfected with HA-CBP and (or) FH-USP12 as indicated, and then treated with mouse IFNβ (500 IU/ml) for 2 hrs.
Qian Feng (302178), Hongguang Zhang (3049518), Yukang Yuan (2883881), Chuanwu Zhu (720446), Jin Liu (12833), Feng Qian (73252), Fan Huang (652515), Xiangjie Chen (8218935), Liting Zhang (2883890), Li Zhu (67404), Tingting Guo (101831), Lincong Jin (8218932), Hui Zheng (58412), Yibo Zuo (2883887), Ying Miao (593867)   +14 more
core   +1 more source

TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma

Advanced Science, EarlyView.
TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin, Cheung Kwan Yeung, Ye Yi, Dejin Zheng, Miaoman Ye, Chi‐Chong Chio, Jinjie Wu, Siyi Fu, Chu‐Xia Deng, Ren‐He Xu   +9 more
wiley   +1 more source

CRISPR/Cas9-mediated knockout of STAT1 in porcine-derived cell lines to elucidate the role of STAT1 in autophagy following classical swine fever virus infection

Frontiers in Immunology
Signal transducer and activator of transcription 1 (STAT1) plays a critical role in immune response, human STAT1 as a transcriptional suppressor of autophagy genes and autophagic activity.
Liyuan Zhang, Liyuan Zhang, Dongli Liang, Dongli Liang, Kaijun Min, Kaijun Min, Jiaxin Liang, Jiaxin Liang, Yu Tian, Yu Tian, Cheng Liu, Cheng Liu, Cheng Liu, Ting Rong Luo, Ting Rong Luo, Ting Rong Luo, Ting Rong Luo, Xiaoning Li, Xiaoning Li, Xiaoning Li, Xiaoning Li   +20 more
doaj   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

STAT3 but Not STAT1 Is Required for Astrocyte Differentiation

PLoS ONE, 2014
The JAK-STAT signaling pathway has been implicated in astrocyte differentiation. Both STAT1 and STAT3 are expressed in the central nervous system and are thought to be important for glial differentiation, as mainly demonstrated in vitro; however direct in vivo evidence is missing.
Seulgi Hong, Mi-Ryoung Song
openaire   +4 more sources

STAT1: A Novel Target of miR-150 and miR-223 Is Involved in the Proliferation of HTLV-I–Transformed and ATL Cells

Neoplasia: An International Journal for Oncology Research, 2015
We have previously reported on the deregulation of cellular microRNAs involved in hematopoiesis and inflammation in human T-cell lymphotropic virus type 1 (HTLV-I)–transformed cells.
Ramona Moles, Marcia Bellon, Christophe Nicot   +2 more
doaj   +1 more source

Fish virus-induced interferon exerts antiviral function through Stat1 pathway

, 2010
Virus-Induced interferons (IFNs) have been identified in various fish species and display antiviral activities similar to mammalian type I IFNs However apart from the mammalian IFN system the IFN signaling pathway remains largely unknown Using transient ...
Yu, Fei-Fei, Liu, Ying, Zhang, Yi-Bing, Sun, Fan, Gui, JF, Chinese Acad Sci, Grad Sch, Inst Hydrobiol, State Key Lab Freshwater Ecol & Biotechnol, Wuhan 430072, Peoples R China, Gui, Jian-Fang, Liu, Ting-Kai, Jiang, Jun   +7 more
core  

Interactions between STAT1 and KAP1 [PDF]

, 2008
Signal transducers and activators of transcription (STATs) mediate cell proliferation, differentiation, and survival in immune responses, hematopoiesis, neurogenesis, and other biological processes.
Sekine, Yuichi, Ohbayashi, Norihiko, Ikeda, Osamu, Togi, Sumihito, Matsuda, Tadashi, Muromoto, Ryuta, Ohta, Kazuhide, Kamitani, Shinya, Ishiyama, Hironobu   +8 more
core   +1 more source