Results 121 to 130 of about 82,953 (296)
Spatial Au+ Mapping Reveals a Self‐Amplifying Anti‐Tumor Immunity Loop Driven by Au(I) Complexes
Advanced Science, EarlyView.The first report of spatial Au+ mapping of a representative gold complex (Au9). Macrophages, DCs, and tumor cells ranked as the top three in Au+ enrichment after Au9 treatment. Interestingly, Au9 treatment could induce ferroptosis and suppress cellular cholesterol, further eliciting a self‐amplifying anti‐tumor immunity loop.
Zhongren Xu +5 more
wiley +1 more source
Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation
Life Science AllianceGlycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNgamma production by maintaining STAT1 S727 phosphorylation.
Ariful Haque Abir +8 more
doaj +1 more source
, 2013 A, Exogenous STAT1 expression after transfection with a vector carrying GFP or eGFP-fused full-length STAT1 cDNA in Caki-1 cells. Cells efficiently expressed exogenous STAT1 at 48 h after transfection.
Kazunori Kihara (339824) +5 more
core +1 more source
Bioenergetic Materials for Tissue Regeneration: Modulating Metabolism to Promote Cellular Anabolism
Advanced Science, EarlyView.Bioenergetic materials (BEMs) modulate cellular metabolism to promote tissue regeneration. Their principal mechanisms of action include metabolic substrate supplementation, metabolic enzyme modulation, organelle transfer, electrical current regulation, redox homeostasis modulation, and oxygen tension modulation.
Yuchen He +7 more
wiley +1 more source
Activation of STAT1 in BKV infected LVEC.
, 2019 A. No nuclear STAT1 was detected in BKV inoculated RPTE1 by IF. B. Double staining of VP1 and STAT1-Y701 showed nuclear translocation of STAT1 in BKV inoculated (lower panel) but not mock (upper panel) LVEC3.
Ping An (24129) +4 more
core +1 more source
Disentangling Heterogeneous Molecular Networks for Multi‐Omics‐Driven Cancer Driver Discovery
Advanced Science, EarlyView.DRIVE integrates PPI topology and pan‐cancer multi‐omics profiles through dual‐view graph disentanglement, contrastive representation learning, and joint optimization. Across six PPI networks, DRIVE outperforms ten baselines and remains robust to structural and annotation perturbations.
Xinjing Gong +8 more
wiley +1 more source
T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease
Advanced Science, EarlyView.This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li +11 more
wiley +1 more source
四川大学学报. 自然科学版, 2015 以长白猪(Landrace)cDNA为模板,克隆STAT1基因cDNA全长.家猪STAT1基因cDNA全长编码757个氨基酸的前体蛋白,与人、大鼠、小鼠、牛等哺乳动物的STAT1氨基酸序列一致性分别为95%、90.8%、89.6%、91.6%;同时,本研究亦鉴定到家猪STAT1的3种剪接变体(分别命名为STAT1-sv1,STAT1-sv2,和STAT1-sv3).采用RT-PCR方法,进一步检测了STAT1及其3种剪接变体在成年家猪各组织中的表达情况.STAT1和两种剪切变体(STAT1 ...
付浩, 孟凤艳, 李芳莲, 李娟
doaj
, 2010 The transcription factor STAT1 is involved in signal transduction of type I and II interferons (IFNs). However, the molecular characteristics of the STAT1 regulatory region still remain to be elucidated in teleosts.
Jia, Weizhang +2 more
core
Activated STAT1 suppresses proliferation of cultured rat mesangial cells [PDF]
, 2000 Activated STAT1 suppresses proliferation of cultured rat mesangial cells.BackgroundJAK-STAT signaling has been shown to promote development and proliferation in lymphopoietic and hematopoietic lineages.
Hanada, Satoko +6 more
core +1 more source