Results 121 to 130 of about 112,289 (303)

CRISPR/Cas9-mediated knockout of STAT1 in porcine-derived cell lines to elucidate the role of STAT1 in autophagy following classical swine fever virus infection

Frontiers in Immunology
Signal transducer and activator of transcription 1 (STAT1) plays a critical role in immune response, human STAT1 as a transcriptional suppressor of autophagy genes and autophagic activity.
Liyuan Zhang, Liyuan Zhang, Dongli Liang, Dongli Liang, Kaijun Min, Kaijun Min, Jiaxin Liang, Jiaxin Liang, Yu Tian, Yu Tian, Cheng Liu, Cheng Liu, Cheng Liu, Ting Rong Luo, Ting Rong Luo, Ting Rong Luo, Ting Rong Luo, Xiaoning Li, Xiaoning Li, Xiaoning Li, Xiaoning Li   +20 more
doaj   +1 more source

Comparison of Varying Tissue Freezing Methods on Murine Colonic Tissue [PDF]

, 2018
Histology often requires a tissue specimen to be embedded so that it may be sectioned, stained, and mounted on a microscope slide for viewing. One common method of tissue embedding for rapid histology is freezing, since freezing allows tissue to be ...
Hughes, James
core   +2 more sources

Origin and pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma as revealed by global gene expression analysis [PDF]

, 2008
The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H ...
Brune, Verena, Bräuninger, Andreas, Döring, Claudia, Eckerle, Susan, Falini, Brunangelo, Hansmann, Martin-Leo, Heydebreck, Anja von, Klapper, Wolfram, Küppers, Ralf, Metzler, Dirk, Pfeil, Ines, Tiacci, Enrico, van Noesel, Carel J. M.   +12 more
core   +1 more source

Selenomethionine Regulates the Arachidonic Acid Metabolism‐Ferroptosis‐Inflammation Axis to Ameliorate Colitis

Animal Research and One Health, EarlyView.
Selenomethionine can ameliorate arachidonic acid‐induced colonic injury through synergistic mechanisms, including alleviating inflammatory responses, improving barrier integrity, enhancing antioxidant capacity by upregulating selenoprotein expression, selectively regulating AA metabolism to reduce pro‐inflammatory oxylipins and promote the production ...
Huihui Tian, Longzhu Zhou, Xiaohui Feng, Jialu Shen, Xiaoping Du, Qingyu Zhao, Yuchang Qin, Junmin Zhang, Chaohua Tang   +8 more
wiley   +1 more source

Novel function of STAT1 in breast cancer [PDF]

OncoImmunology, 2013
In the past, the transcription factor STAT1 was considered as a tumor suppressor. We have recently discovered that STAT1 in malignant cells favors breast cancer progression as it stimulates immunosuppressive effects mediated by myeloid-derived suppressor cells (MDSCs).
openaire   +2 more sources

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Single‐Cell RNA Sequencing Informs Precision Targeting of Monogenic Lupus Associated With IKZF1 Haploinsufficiency

Arthritis &Rheumatology, EarlyView.
Objective This study aimed to investigate the mechanisms of immune dysregulation in a pediatric patient with monogenic lupus driven by IKZF1 haploinsufficiency. Methods Peripheral immune cells from a patient with IKZF1 haploinsufficiency, patients with lupus with no currently known genetic mutations, and healthy controls were analyzed using single‐cell
Qi Zheng, Yejun Tan, Zhaoling Wang, Yanjie Qian, Qian Ma, Danping Shen, Meiping Lu   +6 more
wiley   +1 more source

Integrative single cell RNA‐sequencing and spatial transcriptomics uncovers distinct macrophage‐fibroblast cross‐talk in human hip synovium between patients with femoroacetabular impingement and osteoarthritis

Arthritis &Rheumatology, Accepted Article.
Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova, Alexis Klee, Mina Botros, Victoria L. Hansen, John Reuter, Eliya Tazreena Tashbib, Eloise Fadial, Benjamin F. Ricciardi, Brian Giordano, Chia‐Lung Wu   +9 more
wiley   +1 more source

Glycolytic flux sustains human Th1 identity and effector function via STAT1 glycosylation

Life Science Alliance
Glycolysis sustains STAT1 activity via STAT1 O-glycosylation, which is essential for human Th1 cell differentiation and IFNgamma production by maintaining STAT1 S727 phosphorylation.
Ariful Haque Abir, Julia Benz, Benjamin Frey, Heiko Bruns, Gerhard Krönke, Udo S Gaipl, Kilian Schober, Dimitrios Mougiakakos, Dirk Mielenz   +8 more
doaj   +1 more source

STAT1 and pathogens, not a friendly relationship

Biochimie, 2010
STAT1 belongs to the STAT family of transcription factors, which comprises seven factors: STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT1 is a 91 kDa protein originally identified as the mediator of the cellular response to interferon (IFN) alpha, and thereafter found to be a major component of the cellular response to IFNgamma.
Najjar, Imen, Fagard, Remi
openaire   +3 more sources