Results 141 to 150 of about 112,289 (303)
Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. [PDF]
, 2018 Genome-wide investigations of host-pathogen interactions are often limited by analyses of mixed populations of infected and uninfected cells, which lower sensitivity and accuracy.
Benner, Christopher +9 more
core
Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials
iNew Medicine, EarlyView.ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong +5 more
wiley +1 more source
The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets
iNew Medicine, EarlyView.The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong +5 more
wiley +1 more source
Stat1 Signalweg bei Atherosklerose [PDF]
, 2019 In dieser Dissertation wurde untersucht, ob die Exprimierung des Chemokins Mig, welches von Interferon gamma, einem proinflammatorischen und proatherogenem Zytokin, Stat1 abhängig induziert wird, in der glatten Muskulatur von stark atherosklerotisch umgebauten menschlichen Arterien signifikant ausgeprägter ist als in jener von gesunden beziehungsweise ...
openaire
Interdisciplinary Medicine, EarlyView.SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu +6 more
wiley +1 more source
Research Progress in Diseases Caused by STAT1 Gain-of-Function Mutations
罕见病研究Signal transduction and activator of transcription factor 1(STAT1), one of the important members of the STAT family, is a key cytoplasmic transcription factor and an important component of the JAK-STAT signaling pathway.
LI Linpeng +4 more
doaj +1 more source
The SOX11 transcription factor is a critical regulator of basal-like breast cancer growth, invasion, and basal-like gene expression. [PDF]
, 2016 Basal-like breast cancers (BLBCs) are aggressive breast cancers associated with poor survival. Defining the key drivers of BLBC growth will allow identification of molecules for targeted therapy.
Brown, Powel H +6 more
core +1 more source
Journal of Clinical Laboratory Analysis, EarlyView.Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li +3 more
wiley +1 more source
JEADV Clinical Practice, EarlyView.ABSTRACT Background As solid organ transplantation becomes more prevalent, more patients are living on long‐term immunosuppression, greatly increasing the risk of cutaneous squamous cell carcinoma (cSCC). Although significant improvements have been achieved in the treatment of cSCC, further studies are needed to identify the specific protein expression
William Murray +8 more
wiley +1 more source